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Synthesis 2012(5): 783-787  
DOI: 10.1055/s-0031-1289703
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Total Synthesis of (-)-Pyrenophorol

Jhillu S. Yadav*a, Ganapuram Madhusudhan Reddya,b, Tenneti Srinivasa Raoa, Basi V. Subba Reddya, Ahmad Al Khazim Al Ghamdic
a Natural Product Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 607, India
Fax: +91(40)27160512; e-Mail: yadavpub@iict.res.in;
b University of Hyderabad, Hyderabad 500046, India
c Engineer Abdullah Baqshan for Bee Research, King Saudi University, Saudi Arabia
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Publication History

Received 8 October 2011
Publication Date:
13 February 2012 (online)

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Abstract

An efficient synthetic route has been developed for the synthesis of (-)-pyrenophorol employing Sharpless asymmetric epoxidation, olefin cross-metathesis, and intermolecular Mitsunobu cyclization.

Key words

macrodiolide - stereoselectivity - natural products - Sharpless asymmetric epoxidation - cross-metathesis

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