Abstract
Convenient, scalable and high-yielding approaches to 2,5- and
2,4-dibromo-1,3-thiazole are reported that offer significant improvements
over previously reported approaches. 2,5-Dibromo-1,3-thiazole was
generated in two steps from commercially inexpensive 2-amino-1,3-thiazole,
whereas 2,4-dibromo-1,3-thiazole was generated in a single step
from commercially inexpensive 1,3-thiazolidine-2,4-dione. As part
of this study, convenient approaches to 2-bromo- and 2-iodo-1,3-thiazole
were also developed.
Key words
halogenation - bromine - iodine - 1,3-thiazole - heterocycles
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