An efficient methodology for the synthesis of tetrasubstituted
pyrazines starting from pyrazin-2(1H)-ones
has been elaborated. Diversity in the functionalization and the
beneficial effect of microwave irradiation throughout the methodology
has been demonstrated.
palladium catalysis - copper catalysis - pyrazines - 3,5-dichloropyrazin-2(1H)-ones - microwaves - nucleosides