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Synthesis 2012(7): 1057-1062  
DOI: 10.1055/s-0031-1289727
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

A Convenient One-Step Synthesis of Stable β-Amino Alcohol N-Boranes from α-Amino Acids

Afroditi Pinakaa,b, Georgios C. Vougioukalakis*a,c, Dimitra Dimotikalib, Vassilis Psyharisd, Kyriakos Papadopoulos*a
a Institute of Physical Chemistry, NCSR Demokritos, 15310 Athens, Greece
Fax: +30(210)6511766; e-Mail: kyriakos@chem.demokritos.gr;
b Department of Chemical Engineering, NTU Athens, 15780 Athens, Greece
c Laboratory of Organic Chemistry, Department of Chemistry, University of Athens, Panepistimiopolis Zografou, Athens 15771, Greece
Fax: +30(210)6511766; e-Mail: vougiouk@chem.uoa.gr;
d Institute of Materials Science, NCSR Demokritos, 15310 Athens, Greece
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Publikationsverlauf

Received 23 January 2012
Publikationsdatum:
27. Februar 2012 (online)

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Abstract

Novel, non-cyclic β-amino alcohol N-boranes are isolated from the sodium borohydride-sulfuric acid assisted direct reduction of a series of α-amino acids. The reduction takes place in one step under mild conditions and affords the products in good yields.

Key words

amino acids - β-amino alcohols - reduction - sodium borohydride - β-amino alcohol N-boranes

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