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Synthesis 2012; 44(7): 1102-1108
DOI: 10.1055/s-0031-1290489
DOI: 10.1055/s-0031-1290489
paper
Enantiodivergent Syntheses of Pantolactone and Pantothenic Acid from d-Mannitol
Further Information
Publication History
Received: 26 December 2011
Accepted after revision: 09 February 2012
Publication Date:
05 March 2012 (online)
Abstract
Efficient synthetic routes to both the enantiomers of pantolactone and pantothenic acid have been developed starting from d-mannitol-based d-glyceraldehyde acetonide through its conversion into a protected pantoic acid intermediate followed by either cyclization or amide bond formation with a β-amino ester, and subsequent appropriate deprotection.
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