Enantiodivergent Syntheses of Pantolactone and Pantothenic Acid from 
d-Mannitol

Ishita Sanyal; Piyali Deb Barman; Asish Kumar Banerjee

doi:10.1055/s-0031-1290489

Synthesis, Inhaltsverzeichnis

Synthesis 2012; 44(7): 1102-1108
DOI: 10.1055/s-0031-1290489

paper

Enantiodivergent Syntheses of Pantolactone and Pantothenic Acid from d-Mannitol

Ishita Sanyal

Department of Chemistry, CSIR–Indian Institute of Chemical Biology, 4 Raja S.C. Mullick Road, Jadavpur, Kolkata 700032, India, Fax: +91(33)24735197 eMail: ashisbanerjee@iicb.res.in

,

Piyali Deb Barman

Department of Chemistry, CSIR–Indian Institute of Chemical Biology, 4 Raja S.C. Mullick Road, Jadavpur, Kolkata 700032, India, Fax: +91(33)24735197 eMail: ashisbanerjee@iicb.res.in

,

Asish Kumar Banerjee*

Department of Chemistry, CSIR–Indian Institute of Chemical Biology, 4 Raja S.C. Mullick Road, Jadavpur, Kolkata 700032, India, Fax: +91(33)24735197 eMail: ashisbanerjee@iicb.res.in

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Abstract

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Abstract

Efficient synthetic routes to both the enantiomers of pantolactone and pantothenic acid have been developed starting from d-mannitol-based d-glyceraldehyde acetonide through its conversion into a protected pantoic acid intermediate followed by either cyclization or amide bond formation with a β-amino ester, and subsequent appropriate deprotection.

Key words

syntheses - enantiomers - pantolactone - pantothenic acid - d-mannitol

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Referenzen

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