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Synthesis 2012; 44(10): 1511-1514
DOI: 10.1055/s-0031-1290821
DOI: 10.1055/s-0031-1290821
special topic
Regio- and Stereoselective Copper-Catalyzed Ring Opening of Diheterobicyclic Alkenes with Grignard Reagents
Further Information
Publication History
Received: 01 March 2012
Accepted after revision: 09 March 2012
Publication Date:
11 April 2012 (online)
Abstract
The ring opening of bicyclic hydrazines and bicyclic oxazines with organomagnesium reagents under the influence of copper catalysts allows functionalized cyclopentene and cyclohexene derivatives to be obtained. Whereas complete anti-stereoselective ring opening occurred in all cases, the regioselective outcome turned out to be highly dependent on the reaction conditions used.
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References
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