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Synthesis 2012; 44(16): 2527-2530
DOI: 10.1055/s-0031-1290944
DOI: 10.1055/s-0031-1290944
special topic
Continuous-Flow Microliter Microwave Irradiation in the Synthesis of Isoxazole Derivatives: An Optimization Procedure
Further Information
Publication History
Received: 01 March 2012
Accepted after revision: 15 March 2012
Publication Date:
20 April 2012 (online)


Abstract
An efficient method was developed for the synthesis of 3,4,5-trisubstituted and 3,5-disubstituted isoxazoles by using continuous-flow microwave-heated microreactors. A study on the separate effects of the temperature, continuous-flow regime, and microwave irradiation showed that the continuous-flow regime had important effects for less reactive diketones, where microwave heating enhanced the reaction, permitting the formation of 5-methyl-3-phenylisoxazole, which was not formed in the absence of microwaves.