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Synthesis 2012; 44(14): 2264-2276
DOI: 10.1055/s-0031-1291124
DOI: 10.1055/s-0031-1291124
paper
Palladium-Catalysed Direct Arylation of Heteroaromatics Using Unprotected Iodoanilines with Inhibition of the Amination Reaction
Further Information
Publication History
Received: 19 March 2012
Accepted after revision: 18 April 2012
Publication Date:
13 June 2012 (online)
Abstract
The palladium-catalysed direct arylation of heteroaromatics with unprotected iodoanilines proceeds in moderate to high yields using only 1 mol% Pd(OAc)2 as the catalyst and potassium acetate as the base. No amination reaction was observed under these conditions. A wide variety of heteroarenes have been successfully employed.
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For selected recent examples of palladium-catalysed direct arylations of furans, see:
For selected recent examples of palladium-catalysed direct arylations of thiophenes, see:
For selected recent examples of palladium-catalysed direct arylations of thiazoles, see:
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For selected recent examples of palladium-catalysed direct arylations of pyrroles, see:
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