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Synthesis 2012; 44(17): 2695-2698
DOI: 10.1055/s-0031-1291136
practical synthetic procedures
© Georg Thieme Verlag Stuttgart · New York

Practical One-Pot Synthesis of Protected l-Glyceraldehyde Derivatives

Sebastian Stecko
Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland, Fax: +48(22)6326681   Email: chmiel@icho.edu.pl
,
Michał Michalak
Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland, Fax: +48(22)6326681   Email: chmiel@icho.edu.pl
,
Maciej Stodulski
Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland, Fax: +48(22)6326681   Email: chmiel@icho.edu.pl
,
Łukasz Mucha
Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland, Fax: +48(22)6326681   Email: chmiel@icho.edu.pl
,
Kamil Parda
Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland, Fax: +48(22)6326681   Email: chmiel@icho.edu.pl
,
Bartłomiej Furman
Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland, Fax: +48(22)6326681   Email: chmiel@icho.edu.pl
,
Marek Chmielewski*
Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw, Poland, Fax: +48(22)6326681   Email: chmiel@icho.edu.pl
› Author Affiliations
Further Information

Publication History

Received: 17 January 2012

Accepted after revision: 09 March 2012

Publication Date:
26 June 2012 (online)

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Abstract

A large-scale, simple, economic, and safe procedure for the preparation of l-glyceraldehyde acetonide under conditions, which allow its direct transformation (one-pot) into the desired products (acetylene, imine, nitrone, unsaturated ester) is reported. l-Glyceraldehyde acetonide is obtained from the corresponding ester, which is readily available from l-serine.

Key words

l-glyceraldehyde acetonide - l-glyceraldehyde derivatives - aldehydes - nitrones - acetylenes
 

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