Synthesis and determination of acute and chronic pain activities of 1-[1-(4-methylphenyl)(cyclohexyl)] morpholine as a new phencyclidine derivative in rats

Abbas Ahmadi; Mohsen Khalili; Ramin Hajikhani; Moslem Naserbakht

doi:10.1055/s-0031-1296173

Arzneimittelforschung, Table of Contents

Arzneimittelforschung 2011; 61(2): 92-97
DOI: 10.1055/s-0031-1296173

Analgesics · Anti-inflammatories · Antiphlogistics · Antirheumatic Drugs

Editio Cantor Verlag Aulendorf (Germany)

Synthesis and determination of acute and chronic pain activities of 1-[1-(4-methylphenyl)(cyclohexyl)] morpholine as a new phencyclidine derivative in rats

Abbas Ahmadi

¹Department of Chemistry, Faculty of Science, Islamic Azad University, Karaj branch, Karaj, Iran

,

Mohsen Khalili

²Department of Physiology, Neuroscience and Herbal Medicine Research Centers, Shahed University, Tehran, Iran

,

Ramin Hajikhani

³Department of Physiology, Faculty of Science, Islamic Azad University, Karaj branch, Karaj, Iran

,

Moslem Naserbakht

¹Department of Chemistry, Faculty of Science, Islamic Azad University, Karaj branch, Karaj, Iran

› Author Affiliations

Abstract

Phencyclidine (1-(1-phenylcyclohexyl)piperidine, CAS 77-10-1, PCP, I) and many of its analogues have been synthesized and their pharmacological properties studied. In this research, new methyl morpholine derivative of phencyclidine (1-[1-(4-methylphenyl)(cyclohexyl)] morpholine, Methyl-PCM, III) was synthesized and the acute and chronic pain activities were studied using tail immersion and formalin tests on rats and compared to PCP and PCM (1-(1-phenylcyclohexyl)-morpholine, CAS 2201-40-3, PCP-mor-pholine, II).

The results indicated that Methyl-PCM (III, 6 mg/kg, i.p) produces more analgesic effects in tail immersion test (as a model of acute thermal pain) in comparison with the PCP, PCM and control groups. Meanwhile, this analgesic effect was markedly shown 5-15 min after the compound III application. In formalin test analysis, the acute pain (phase I) could not be affected by any drugs, but the chronic formalin pain (phase II) could be diminished by PCM and especially compound III. The chronic analgesic effect of Methyl-PCM was markedly shown in the late phase of chronic pain.

Key words

Acute and chronic pain - CAS 77-10-1 - CAS 2201-40-3 - Methyl morpholine derivative of phencyclidine - Tail immersion and formalin tests

Full Text

References

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