Planta Medica, Table of Contents Planta Med 2012; 78(09): 906-908DOI: 10.1055/s-0031-1298537 Biological and Pharmacological Activity Letters Georg Thieme Verlag KG Stuttgart · New York Leishmanicidal Compounds from the Fruits of Piper longum Sabari Ghosal 1 Amity Institute of Biotechnology, Amity University, Noida, India , Anindita Deb 2 Department of Bioorganic Chemistry, National Institute of Immunology, New Delhi, India , Priyanka Mishra 1 Amity Institute of Biotechnology, Amity University, Noida, India , Ram Vishwakarma 2 Department of Bioorganic Chemistry, National Institute of Immunology, New Delhi, India › Author Affiliations Recommend Article Abstract Buy Article Abstract One new alkaloid amide, piperlongumide (1) [N-isobutyl-19-(3′,4′-methylenedioxyphenyl)-2E,4E nonadecadienamide], and six known compounds with leishmanicidal activity against promastigotes and axenic amastigotes of Leishmania donovani were isolated from the n-hexane fraction of the fruits of Piper longum. The structure of 1 was elucidated by spectroscopic evidences. Key words Key words Piper longum - Piperaceae - piperlongumide - Leishmania donovani - promastigotes - axenic amastigotes Full Text References References 1 Rocha LG, Almeida JRGS, Macedo RO, Barbosa-Filho JMA. A review of natural products with antileishmanial activity. Phytomedicine 2005; 2: 514-535 2 Chan-Bacab MJ, Pena-Rodriguez LM. Plant natural products with leishmanicidal activity. Nat Prod Rep 2010; 18: 674-688 3 Kumar S, Arya P, Mukherjee C, Singh BK, Singh N, Parmar VS, Prasad AK, Ghosh B. Novel aromatic ester from Piper longum and its analogues inhibit expression of cell adhesion molecules on endothelial cells. Biochemistry 2005; 44: 15944-15952 4 Parmar VS, Jain SC, Bisht KS, Jain R, Taneja P, Jha A, Tyagi OD, Prasad AK, Wengel J, Olsen CE, Boll PM. Phytochemistry of the genus Piper . Phytochemistry 1997; 4: 597-603 5 Mishra P, Sinha S, Guru SK, Bhushan S, Vishwakarma RA, Ghosal S. Two new amides with cytotoxic activity from the fruits of Piper longum . J Asian Nat Prod Res 2011; 13: 143-148 6 Singh SK, Bimal S, Narayan S, Jee E, Bimal D, Das P, Bimal R. Leishmania donovani: assessment of leishmanicidal effects of herbal extracts obtained from plants in the visceral leishmaniasis endemic area of Bihar, India. Exp Parasitol 2011; 127: 552-558 7 Kapil A. Piperine, a potent inhibitor of Leishmania donovani promastigotes in vitro . Planta Med 1993; 59: 475 8 Banerji A, Sarkar M, Datta R, Sengupta P, Abraham K. Amides from Piper brachystachyum and Piper retrofractum . Phytochemistry 2002; 59: 897-901 9 Banerji A, Das C. Two amides from Piper brachystachyum . Phytochemistry 1989; 28: 3039-3042 10 Dutta A, Bandopadhyay S, Mandal C, Chatterjee M. Development of a modified MTT assay for screening antimonial resistant field isolates of Indian visceral leishmaniasis. Parasitol Int 2005; 54: 119-122 11 Pan AA, Duboise SM, Eperon S, Rivas L, Hodgkinson V, Ttraub-Cseko Y, Mcmohan-Pratt D. Developmental life cycle of leishmania-cultivation and characterization of cultured extracellular amastigotes. J Eukaryot Microbiol 1993; 40: 213-223 12 Manandhar KD, Jadav TP, Prajapati VK, Kumar S, Rai M, Dube A, Srivastava ON, Sundar S. Antileishmanial activity of nano-amphotericine B deoxycholate. J Antimicrob Chemother 2008; 62: 376-380
