Critical Evaluation of Mouse Models Used to Study Pain and Loss of Pain Perception in Diabetic Neuropathy

A. Bierhaus; P. P. Nawroth

doi:10.1055/s-0032-1304567

Experimental and Clinical Endocrinology & Diabetes, Table of Contents

Exp Clin Endocrinol Diabetes 2012; 120(04): 188-190
DOI: 10.1055/s-0032-1304567

Mini-Review Series on Diabetes and its Complications

Critical Evaluation of Mouse Models Used to Study Pain and Loss of Pain Perception in Diabetic Neuropathy

A. Bierhaus

¹Department of Medicine I and Clinical Chemistry, University of Heidelberg, Heidelberg, Germany

,

P. P. Nawroth

¹Department of Medicine I and Clinical Chemistry, University of Heidelberg, Heidelberg, Germany

› Author Affiliations

Abstract

A number of studies have addressed diabetic neuropathy (DN) in transgenic and knock out mouse models to unravel the molecular mechanisms underlying metabolic pain and loss of pain perception. However, it is difficult to compare these studies with each other or even with human DN due to experimental differences including the type of diabetes, the background strain of the respective mouse model, the methods of diabetes induction and the duration of diabetes, animal age and gender. To receive useful information for DN from genetically modified mice, it is therefore mandatory to first define the appropriate model and – if necessary – to backcross transgenic strains into the respective background to allow a reliable (and at least in part translatable to human DN) interpretation of the results.

Key words

diabetes - neuropathy - animal models

Full Text

References

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