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DOI: 10.1055/s-0032-1305013
Antidepressive Therapieoptimierung in einem Fall von chronisch-entzündlicher Darmerkrankung bei unipolarer Depression
Optimizing Antidepressant Pharmacotherapy in a Case of Inflammatory Bowel Disease and Major DepressionPublication History
Publication Date:
11 June 2012 (online)
![](https://www.thieme-connect.de/media/psychiat-praxis/201205/lookinside/thumbnails/10.1055-s-0032-1305013-1.jpg)
Zusammenfassung
Anliegen: Dieser Fallbericht befasst sich mit den pharmakotherapeutischen Therapieoptionen bei subtherapeutischen Medikamentenspiegeln eines Patienten mit chronisch-entzündlicher Darmerkrankung und rezidivierender depressiver Störung.
Methode: Bei erniedrigten Plasmaspiegeln von Mirtazapin wendeten wir therapeutisches Drug Monitoring (TDM), Cytochrom-P450-2D6-Genotypisierung und die Umstellung der Galenik auf eine Darreichungsform mit oraler Wirkstofffreisetzung an.
Ergebnisse und Schlussfolgerung: Dadurch erzielten wir einen Anstieg der Plasmaspiegel von Mirtazapin und eine klinische Besserung.
Abstract
Objective: In the framework of a case report on a patient suffering from major depression and inflammatory bowel disease we address the pharmacotherapeutical options in case of subtherapeutic mirtazapine levels.
Methods: We applied therapeutic drug monitoring (TDM) and cytochrome P450 2D6 genotyping, and switched to an orodispersible tablet.
Results and Conclusion: Thus, mirtazapine plasma levels could be raised and clinical improvement of the depressive symptoms was achieved.
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