Many new and exciting endoscopy-related studies on Barrett’s esophagus, reflux esophagitis, and eosinophilic esophagitis were presented during the 2012 Digestive Disease Week (DDW; 19 – 22 May, San Diego, California, USA). Endoscopic research in Barrett’s esophagus mainly focused on surveillance, detection, and ablation therapy, while clinical studies in eosinophilic esophagitis concerned budesonide treatment and dietary measures, and those on reflux esophagitis covered various issues related to anti-reflux surgery. In this review, we discuss our top 20 DDW 2012 abstracts on these three topics.