Preimplantation Genetic Diagnosis Comes of Age

References
1 Handyside AH, Kontogianni EH, Hardy K, Winston RM. Pregnancies from biopsied human preimplantation embryos sexed by Y-specific DNA amplification. Nature 1990; 344 (6268) 768-770
2 Harper JC, Coonen E, De Rycke M , et al. ESHRE PGD Consortium data collection X: cycles from January to December 2007 with pregnancy follow-up to October 2008. Hum Reprod 2010; 25 (11) 2685-2707
3 Handyside A. Let parents decide. Nature 2010; 464 (7291) 978-979
4 Verlinsky Y, Rechitsky S, Evsikov S , et al. Preconception and preimplantation diagnosis for cystic fibrosis. Prenat Diagn 1992; 12 (2) 103-110
5 Hardy K, Martin KL, Leese HJ, Winston RM, Handyside AH. Human preimplantation development in vitro is not adversely affected by biopsy at the 8-cell stage. Hum Reprod 1990; 5 (6) 708-714
6 Handyside AH, Lesko JG, Tarín JJ, Winston RM, Hughes MR. Birth of a normal girl after in vitro fertilization and preimplantation diagnostic testing for cystic fibrosis. [see comments]. N Engl J Med 1992; 327 (13) 905-909
7 Griffin DK, Handyside AH, Penketh RJ, Winston RM, Delhanty JD. Fluorescent in-situ hybridization to interphase nuclei of human preimplantation embryos with X and Y chromosome specific probes. Hum Reprod 1991; 6 (1) 101-105
8 Munné S, Lee A, Rosenwaks Z, Grifo J, Cohen J. Diagnosis of major chromosome aneuploidies in human preimplantation embryos. Hum Reprod 1993; 8 (12) 2185-2191
9 Munné S, Alikani M, Tomkin G, Grifo J, Cohen J. Embryo morphology, developmental rates, and maternal age are correlated with chromosome abnormalities. Fertil Steril 1995; 64 (2) 382-391
10 Munné S, Weier HU, Grifo J, Cohen J. Chromosome mosaicism in human embryos. Biol Reprod 1994; 51 (3) 373-379
11 Delhanty JD, Griffin DK, Handyside AH , et al. Detection of aneuploidy and chromosomal mosaicism in human embryos during preimplantation sex determination by fluorescent in situ hybridisation (FISH). Hum Mol Genet 1993; 2 (8) 1183-1185
12 Mastenbroek S, Twisk M, van Echten-Arends J , et al. In vitro fertilization with preimplantation genetic screening. N Engl J Med 2007; 357 (1) 9-17
13 Handyside AH, Harton GL, Mariani B , et al. Karyomapping: a universal method for genome wide analysis of genetic disease based on mapping crossovers between parental haplotypes. J Med Genet 2010; 47 (10) 651-658
14 Bell CJ, Dinwiddie DL, Miller NA , et al. Carrier testing for severe childhood recessive diseases by next-generation sequencing. Sci Transl Med 2011; 3 (65) 66ra4
15 Handyside AH. Preimplantation genetic diagnosis after 20 years. Reprod Biomed Online 2010; 21 (3) 280-282
16 Tur-Kaspa I, Aljadeff G, Rechitsky S, Grotjan HE, Verlinsky Y. PGD for all cystic fibrosis carrier couples: novel strategy for preventive medicine and cost analysis. Reprod Biomed Online 2010; 21 (2) 186-195
17 Lo YM, Chan KC, Sun H , et al. Maternal plasma DNA sequencing reveals the genome-wide genetic and mutational profile of the fetus. Sci Transl Med 2010; 2 (61) 61ra91