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Planta Med 2012; 78(14): 1591-1596
DOI: 10.1055/s-0032-1315079
Natural Product Chemistry
Letters
Georg Thieme Verlag KG Stuttgart · New York

New Xanthone Glycosides from Comastoma pedunculatum

Yongqi Qiao
1   State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China
,
Yi Yuan
1   State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China
,
Baosong Cui
1   State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China
,
Ying Zhang
1   State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China
,
Hui Chen
1   State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China
,
Shuai Li
1   State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China
,
Yan Li
1   State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China
› Author Affiliations
Further Information

Publication History

received 21 December 2011
revised 20 June 2012

accepted 25 June 2012

Publication Date:
18 July 2012 (online)

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Abstract

Five new xanthone glycosides, comastomasides A–E (1–5), were isolated from aqueous ethanol extracts of the aerial portions of Comastoma pedunculatum. The structures of these compounds were elucidated by spectroscopic analysis methods. Compounds 1–5 were evaluated for their hepatoprotective activity and cytotoxicity against four human cancer cell lines by in vitro assays. Among them, compounds 3 and 5 exhibited potent hepatoprotective activity. However, none of the compounds displayed cytotoxic activity.

Key words

Comastoma pedunculatum - Gentianaceae - xanthone glycosides - hepatoprotective activity

Supporting Information

 

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