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Planta Med 2012; 78(14): 1574-1578
DOI: 10.1055/s-0032-1315111
Natural Product Chemistry
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

New Monoterpenes, Diterpenes, and Lignans from Abies recurvata

Yong-Li Li
1   School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China
,
Ji-Gang Zhang
2   School of Pharmacy, Second Military Medical University, Shanghai, China
,
Ping Yu
2   School of Pharmacy, Second Military Medical University, Shanghai, China
,
Bei-Lei Ke
2   School of Pharmacy, Second Military Medical University, Shanghai, China
,
Ji Ye
2   School of Pharmacy, Second Military Medical University, Shanghai, China
,
Xian-Wen Yang
3   Laboratory of Molecular and Cellular Oncology, Oncology Department, Luxembourg Public Research Center for Health (CRP-Santé), Luxembourg, Luxembourg
4   Key Laboratory of Marine Bio-resources Sustainable Utilization, Guangdong Key Laboratory of Marine Materia Medica, and RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China
,
Hui-Zi Jin
1   School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China
,
Wei-Dong Zhang
1   School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China
2   School of Pharmacy, Second Military Medical University, Shanghai, China
› Author Affiliations
Further Information

Publication History

received 27 May 2012
revised 25 June 2012

accepted 29 June 2012

Publication Date:
19 July 2012 (online)

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Abstract

From the aerial part of Abies recurvata, 62 miscellaneous chemical constituents were isolated including 6 new and 56 known ones. The new compounds comprised three monoterpenes, two diterpenes, and one lignan. Their chemical structures were characterized on the basis of various spectroscopic techniques. Dihydrodehydrodiconiferyl alcohol (35) showed the strongest inhibitory effects against lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells with an IC50 value of 66.4 µM.

Key words

Abies recurvate - Pinaceae - monoterpenes - diterpenes - lignin - nitric oxide - lipopolysaccharide

Supporting Information

 

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