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Planta Med 2012; 78(16): 1780-1783
DOI: 10.1055/s-0032-1315372
Letters
Georg Thieme Verlag KG Stuttgart · New York

A Phenolic Derivative and Two Diacetylenes from Symphyotrichum subulatum

Kai Lee
1   Department of Chemistry, Chinese Culture University, Taipei, Taiwan
,
Chien-Chang Shen
2   National Research Institute of Chinese Medicine, Taipei, Taiwan
,
Chwan-Fwu Lin
3   Department of Cosmetic Science, Chang Gung University of Science and Technology, Tao-Yuan, Taiwan
,
Shyh-Yuan Li
1   Department of Chemistry, Chinese Culture University, Taipei, Taiwan
,
Yu-Ling Huang
2   National Research Institute of Chinese Medicine, Taipei, Taiwan
3   Department of Cosmetic Science, Chang Gung University of Science and Technology, Tao-Yuan, Taiwan
› Author Affiliations
Further Information

Publication History

received 20 April 2012
revised 27 June 2012

accepted 22 August 2012

Publication Date:
24 September 2012 (online)

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Abstract

A pytochemical study on the constituents of the roots of Symphyotrichum subulatum led to the isolation of three new compounds including two diacetylenes, asterynes A (1) and B (2), and (E)-4-(3-acetoxyprop-1-enyl)-2-methoxyphenyl (S)-2-methylbutanoate (3) along with twelve known compounds. Their structures were elucidated with spectroscopic analyses. Compound 3 showed anti-inflammatory activity on LPS-induced NO production with an EC50 value of 15.0 µM.

Key words

Symphyotrichum subulatum - Asteraceae - asteryne A - asteryne B - (E)-4-(3-acetoxyprop-1-enyl)-2-methoxyphenyl (S)-2-methylbutanoate - anti-inflammatory

Supporting Information

 

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