One-Pot Synthesis of 5-Acyl-2-amino-1,3,4-thiadiazoles

Abstract

A novel two-step one-pot synthesis of 5-acyl-2-amino-1,3,4-thiadiazoles by the reaction of acyl chlorides with N-isocyanoiminotriphenylphosphorane in the presence of KSCN is described. It was found that THF and KSCN are the key reagents to obtain the desired products in high isolated yields.

Key words

acylation - heterocycles - cyclization - addition - ketones

• References

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