1,6-Conjugate Addition of Nucleophiles to α,β,γ,δ-Diunsaturated Systems

Synthesis 2012; 44(20): 3109-3128
DOI: 10.1055/s-0032-1316778

review

Eduarda M. P. Silva

Department of Chemistry & QOPNA, University of Aveiro, 3810-193 Aveiro, Portugal Fax: +351(234)370714 eMail: artur.silva@ua.pt

,

Artur M. S. Silva*

Department of Chemistry & QOPNA, University of Aveiro, 3810-193 Aveiro, Portugal Fax: +351(234)370714 eMail: artur.silva@ua.pt

Herein, an overview of the most important developments and concepts related to the 1,6-conjugate addition reactions are reviewed.

1 Introduction

2 Transition-Metal-Catalyzed 1,6-Conjugate Additions

2.1 Copper-Mediated Reactions

2.2 Iron-Mediated Reactions

2.3 Rhodium- and Iridium-Mediated Reactions

3 Organocatalyzed 1,6-Conjugate Additions

4 Other Methods

5 Conclusions

1,6-conjugate addition - nucleophiles - organocatalysis - asymmetric synthesis - enantioselectivity

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