Conjugate addition of a variety of aryl lithiocyanocuprates to nitrosoalkenes generated from α-chloro aldoximes, followed by in situ dehydration of the crude α-aryl aldoxime product with N,N′-dicyclohexylcarbodiimide, affords α-aryl nitriles in good overall yields via a one-pot protocol.
Key words
cuprates - nucleophilic addition - nitriles - aldehydes - arylation