Efficient Synthesis of 3,7-Diaryl-1,4-dihydro[1,2,4]triazolo[5,1-c][1,2,4]triazines

Abstract

An efficient and versatile protocol for the synthesis of novel 3,7-diaryl-substituted 1,4-dihydro[1,2,4]triazolo[5,1-c][1,2,4]triazines is described, via alkylation/cyclization of 3,5-dibromo-1H-1,2,4-triazole, followed by Suzuki coupling with arylboronic acids.

Key words

heterocycles - fused-ring systems - antiviral agents - alkylation - cyclization - cross-coupling

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