Synthesis 2012; 44(21): 3361-3365
DOI: 10.1055/s-0032-1317340
paper
© Georg Thieme Verlag Stuttgart · New York

NbCl5-Promoted Synthesis of 4-Aryl-3,4-dihydrocoumarins by Multicomponent Reaction

Willian Henrique dos Santos
Department of Chemistry, São Paulo State University (UNESP), 17033-360, Bauru, São Paulo, Brazil   Fax: +55(14)31036099   Email: lcsilva@fc.unesp.br
,
Luiz Carlos da Silva-Filho*
Department of Chemistry, São Paulo State University (UNESP), 17033-360, Bauru, São Paulo, Brazil   Fax: +55(14)31036099   Email: lcsilva@fc.unesp.br
› Author Affiliations
Further Information

Publication History

Received: 02 August 2012

Accepted after revision: 10 September 2012

Publication Date:
20 September 2012 (online)


Abstract

Substituted 4-aryl-3,4-dihydrocoumarins are synthesized from multicomponent reactions between phenols, dimethyl malonate, and aryl aldehydes catalyzed by niobium pentachloride. This new method is simple, cost-effective, and high-yielding, and can be conducted in acceptable reaction times.

Supporting Information

 
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