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Synthesis 2013; 45(7): 888-892
DOI: 10.1055/s-0032-1318156
DOI: 10.1055/s-0032-1318156
practical synthetic procedures
Transfer Hydrogenations of Alkenes with Formate on Pd/C: Synthesis of Dihydrocinchona Alkaloids
Further Information
Publication History
Received: 08 January 2013
Accepted after revision: 14 January 2013
Publication Date:
14 February 2013 (online)
Abstract
Protocols for preparative (1–80 gram scale) transfer hydrogenations of alkenes over a palladium on carbon catalyst using formic acid/ammonium formate as hydrogen donor are presented. Cinchona alkaloids have been converted to their dihydro derivatives in >94% yield.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information
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Hydrogenation of the alkaloids in dilute H2SO4 with PdCl2 and H2 close to regular pressure has been described: