Transfer Hydrogenations of Alkenes with Formate on Pd/C: Synthesis of 
Dihydrocinchona Alkaloids

Haotian Wu; Lukas Hintermann

doi:10.1055/s-0032-1318156

Synthesis, Table of Contents

Synthesis 2013; 45(7): 888-892
DOI: 10.1055/s-0032-1318156

practical synthetic procedures

Transfer Hydrogenations of Alkenes with Formate on Pd/C: Synthesis of Dihydrocinchona Alkaloids

Haotian Wu

Department Chemie, Technische Universität München, Lichtenbergstrasse 4, 85748 Garching bei München, Germany Fax: +49(89)28913669 Email: lukas.hintermann@tum.de

,

Lukas Hintermann*

Department Chemie, Technische Universität München, Lichtenbergstrasse 4, 85748 Garching bei München, Germany Fax: +49(89)28913669 Email: lukas.hintermann@tum.de

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Abstract

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Abstract

Protocols for preparative (1–80 gram scale) transfer hydrogenations of alkenes over a palladium on carbon catalyst using formic acid/ammonium formate as hydrogen donor are presented. Cinchona alkaloids have been converted to their dihydro derivatives in >94% yield.

Key words

alkaloids - alkenes - catalysis - hydrogen transfer - hydrogenation - palladium

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References

References
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