Synlett 2013; 24(5): 619-624
DOI: 10.1055/s-0032-1318237
letter
© Georg Thieme Verlag Stuttgart · New York

Nickel-Catalyzed Reductive Cross-Coupling of Aryl Halides

Qun Qian*
,
Zhenhua Zang
,
Shulin Wang
,
Yang Chen
,
Kunhua Lin*
,
Hegui Gong
Further Information

Publication History

Received: 27 December 2012

Accepted after revision: 28 January 2013

Publication Date:
20 February 2013 (online)


Abstract

This work highlights unsymmetrical biaryl compounds via direct nickel-catalyzed reductive coupling of two aryl halides. By tuning the ligand structures, the reaction of two electron-enriched aryl halides also provided the coupling product in good yields, with an excess of 1.4 equivalents of one of the halides. The mild reaction conditions display excellent functional-group tolerance and generally gave the coupling products in moderate to good yields. In addition to aryl bromides, activated aryl chlorides are effective.

Supporting Information