Normal Circulating PTH in Saudi Healthy Individuals with Hypovitaminosis D

Y. Al-Saleh; N. M. Al-Daghri; K. M. Alkharfy; O. S. Al-Attas; M. S. Alokail; A. Al-Othman; S. Sabico; G. P. Chrousos

doi:10.1055/s-0032-1323679

Hormone and Metabolic Research, Table of Contents

Horm Metab Res 2013; 45(01): 43-46
DOI: 10.1055/s-0032-1323679

Humans, Clinical

Normal Circulating PTH in Saudi Healthy Individuals with Hypovitaminosis D

Y. Al-Saleh

¹Prince Mutaib Chair for Biomarkers of Osteoporosis, King Saud University, Riyadh, KSA

²College of Medicine, King Saud University of Health Sciences, Riyadh, KSA

,

N. M. Al-Daghri

¹Prince Mutaib Chair for Biomarkers of Osteoporosis, King Saud University, Riyadh, KSA

³Biomarkers Research Program, Biochemistry Department, College of Science, King Saud University, Riyadh, KSA

⁴Center of Excellence in Biotechnology Research Center, King Saud University, Riyadh, KSA

,

K. M. Alkharfy

¹Prince Mutaib Chair for Biomarkers of Osteoporosis, King Saud University, Riyadh, KSA

²College of Medicine, King Saud University of Health Sciences, Riyadh, KSA

⁵Clinical Pharmacy Department, College of Pharmacy, King Saud University, Riyadh, KSA

,

O. S. Al-Attas

¹Prince Mutaib Chair for Biomarkers of Osteoporosis, King Saud University, Riyadh, KSA

³Biomarkers Research Program, Biochemistry Department, College of Science, King Saud University, Riyadh, KSA

⁴Center of Excellence in Biotechnology Research Center, King Saud University, Riyadh, KSA

,

M. S. Alokail

¹Prince Mutaib Chair for Biomarkers of Osteoporosis, King Saud University, Riyadh, KSA

³Biomarkers Research Program, Biochemistry Department, College of Science, King Saud University, Riyadh, KSA

⁴Center of Excellence in Biotechnology Research Center, King Saud University, Riyadh, KSA

,

A. Al-Othman

⁶College of Applied Medical Sciences, King Saud University, Riyadh, KSA

,

S. Sabico

³Biomarkers Research Program, Biochemistry Department, College of Science, King Saud University, Riyadh, KSA

,

G. P. Chrousos

³Biomarkers Research Program, Biochemistry Department, College of Science, King Saud University, Riyadh, KSA

⁷First Department of Pediatrics, Athens University Medical School, Athens, Greece

› Author Affiliations

Abstract

Recent studies in the Middle East have shown an increased incidence of vitamin D deficiency across this region of year-round sunlight. There is scarcity of information, however, as to the levels of 1,25-dihydroxyvitamin D [1,25(OH)₂D], the active form of vitamin D, and its associations with cardiometabolic parameters in an Arab cohort and this study aims to fill this gap. In a cross-sectional study, 33 male and 43 female (22 children and 54 adults, total 76) Saudis with previously established low levels of serum 25-hydroxyvitamin D [25(OH)D] (<50 ng/ml or 20 nmol/l) were recruited. Anthropometrics were obtained and fasting blood samples were taken for a routine measurement of glucose, lipid profile, calcium, and albumin, while serum 25(OH)D, 1,25-(OH)₂D, and intact PTH were quantified using specific ELISAs. Serum calcium, intact PTH, and 1,25(OH)₂D were all within the normal range in both children and adults in both genders. In all subjects, serum 1,25(OH)₂D was not associated with intact PTH, while circulating 1,25(OH)D inversely correlated with systolic blood pressure (p=0.01) and waist circumference (p=0.04). Thus, vitamin D deficient Saudi children and adults with normal levels of 1,25-(OH)₂D also had normal circulating calcium and PTH. This study suggests that local cutoffs should be set that will be of clinical significance in the identification of those at true risk for harder end-points, such as secondary hyperparathyroidism and bone-related diseases.

Key words

vitamin D - 1, 25-dihydroxyvitamin D - PTH - Saudi Arab

Full Text

References

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