Pharmacokinetic Evaluation of Visnagin and Ammi visnaga Aqueous Extract after Oral Administration in Rats

Erratum for: Pharmacokinetic Evaluation of Visnagin and Ammi visnaga Aqueous Extract after Oral Administration in Rats

Published in Planta Medica 2012; 78 (17): 1831–1836

[Table 1] has been corrected.

Table 1 Results of non-compartmental analysis (median (SD)). VG: visnagin, AVE: Ammi visnaga extract, N: number of subjects, AUC_last: AUC over the time interval from zero to last quantifiable time point, AUC_inf: AUC over the time interval from zero extrapolated to infinity, C_max: maximum observed concentration, t_max: time at C_max, λ_z: terminal elimination rate constant, t_1/2: terminal half-life, AUMC_last: AUMC over the time interval from zero to last quantifiable time point, AUMC_inf: AUMC over the time interval from zero extrapolated to infinity, MRT_last: mean residence time over the time interval from zero to last quantifiable time point, MRT_inf: mean residence time over the time interval from zero extrapolated to infinity, CL/F: clearance uncorrected for oral bioavailability (F), V_z/F: volume of distribution during the terminal phase λ_z uncorrected for F.

Dosing Group (mg/kg)	2.5		5		10
Compound	VG	AVE	VG	AVE	VG	AVE
N	8	7	8	6	8	5
+ Plasma concentration-time profiles with an extrapolated AUC greater than 50 % were excluded from calculation for those parameters, N = 7, 7, 8, 6, 6, 5 ++ Plasma concentration-time profiles with an extrapolated AUMC greater than 50 % were excluded from calculation for those parameters, N = 7, 7, 8, 6, 4, 5
AUClast (mg*h/L)	0.21 (0.29)	2.72 (0.65)	2.45 (2.40)	10.11 (2.66)	9.85 (4.09)	35.42 (11.59)
AUCinf (mg*h/L)+	0.15 (0.33)	2.72 (0.67)	2.45 (2.49)	10.22 (2.49)	10.14 (7.86)	35.67 (11.42)
AUC extrap. (%)+	0.10 (2.37)	0.08 (3.99)	0.05 (4.45)	0.05 (5.22)	6.06 (16.84)	0.71 (1.31)
Cmax (mg/L)	0.17 (0.15)	0.52 (0.15)	0.84 (0.63)	1.38 (0.45)	2.03 (0.85)	3.61 (0.47)
tmax (h)	0.42 (0.36)	1 (1.67)	1 (0.52)	2 (1.86)	1 (0.53)	6 (3.27)
λz (1/h) +	2.46 (0.88)	0.81 (0.21)	1.39 (0.72)	0.67 (0.75)	0.36 (0.94)	0.39 (0.13)
t1/2 (h) +	0.28 (0.45)	0.86 (0.41)	0.50 (0.57)	1.14 (2.88)	1.94 (2.19)	1.77 (0.83)
AUMClast (mg*h2/L)	0.23 (0.56)	10.56 (2.82)	4.89 (5.74)	50.00 (6.43)	29.24 (16.62)	227.8 (110.7)
AUMCinf (mg*h2/L)++	0.10 (0.77)	10.59 (3.55)	4.90 (6.60)	52.00 (19.40)	21.14 (12.17)	235.0 (107.7)
AUMC extrap. (%)++	0.63 (8.19)	0.28 (9.14)	0.16 (12.15)	0.17 (18.75)	7.50 (11.24)	3.06 (3.51)
MRTlast (h)	1.05 (0.55)	3.58 (0.49)	2.37 (0.49)	4.62 (0.77)	3.37 (0.66)	6.43 (1.26)
MRTinf (h)++	1.04 (0.62)	3.58 (0.71)	2.45 (0.59)	4.69 (2.19)	2.84 (0.73)	6.59 (1.16)
CL/F (L/h) +	5.24 (5.47)	0.30 (0.08)	0.65 (0.41)	0.17 (0.04)	0.31 (0.26)	0.10 (0.04)
Vz/F (L) +	1.86 (2.38)	0.41 (0.22)	0.62 (0.33)	0.26 (0.77)	0.86 (0.87)	0.36 (0.25)