Effect of Zeolite Nano-Materials and Artichoke (Cynara scolymus L.) Leaf Extract on Increase in Urinary Clearance of Systematically Absorbed Nicotine

R. E. Malekshah; R. Mahjub; M. Rastgarpanah; M. Ghorbani; A. R. Partoazar; S. E. Mehr; A. R. Dehpour; F. A. Dorkoosh

doi:10.1055/s-0032-1330018

Arzneimittelforschung, Table of Contents

Arzneimittelforschung 2012; 62(12): 650-654
DOI: 10.1055/s-0032-1330018

Original Article

Effect of Zeolite Nano-Materials and Artichoke (Cynara scolymus L.) Leaf Extract on Increase in Urinary Clearance of Systematically Absorbed Nicotine

R. E. Malekshah

¹Department of Inorganic Chemistry, Faculty of Chemistry, Razi University, Kermanshah, Iran

,

R. Mahjub

²Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

³School of Pharmacy, Hamedan University of Medical Sciences, Hamedan, Iran

,

M. Rastgarpanah

⁴Clinical Pharmacy Department, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

,

M. Ghorbani

⁵Danish Technical University of Denmark, Copenhagen, Denmark

,

A. R. Partoazar

⁶Department of Pharmacology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran

,

S. E. Mehr

⁶Department of Pharmacology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran

,

A. R. Dehpour

⁶Department of Pharmacology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran

,

F. A. Dorkoosh

²Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

› Author Affiliations

Abstract

Nicotine, the main pharmacologically active component in tobacco and cigarette, has some toxic effects and also high potential for addiction. In this study, the effect of artichoke (Cynara scolymus L.) and zeolite nano-materials on urinary excretion of nicotine and consequently elimination of systematically absorbed nicotine was investigated. A simple, valid and highly sensitive high performance liquid chromatography method has been developed for determination of nicotine in rat urine according to guidelines for bioanalysis.

It was found that nano-zeolites can cause increase in urinary concentration of nicotine due to its high surface adsorption. Artichoke leaf extract can cause increase in urinary excretion of nicotine in longer post administration times. It was observed that co-administration of nanozeolites and the leaf extract has the synergetic effect on increasing the urinary excretion of nicotine.

Key words

nicotine - high performance liquid chromatography - artichoke leaf extracts (ALE) - zeolite nano-materials

Full Text

References

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