PDF herunterladen
Thorac Cardiovasc Surg 2013; 61(08): 754-757
DOI: 10.1055/s-0033-1336831
Special Report
Georg Thieme Verlag KG Stuttgart · New York

Severe ARDS Induced by Fusobacterial Infections: A Rare Clinical Presentation of Lemierre Syndrome

Jens Litmathe
1   Department of Thoracic Surgery and Lung Support, Ibbenbueren General Hospital, Ibbenbueren, Germany
,
P. Zardo
1   Department of Thoracic Surgery and Lung Support, Ibbenbueren General Hospital, Ibbenbueren, Germany
,
N. Dickgreber
2   Department of Respiratory Medicine and Thoracic Oncology, Ibbenbueren General Hospital, Ibbenbueren, Germany
,
G. May
2   Department of Respiratory Medicine and Thoracic Oncology, Ibbenbueren General Hospital, Ibbenbueren, Germany
,
C. Sucker
3   Labomed Coagulation Center, Berlin, Germany
,
S. Fischer
1   Department of Thoracic Surgery and Lung Support, Ibbenbueren General Hospital, Ibbenbueren, Germany
› Institutsangaben
Weitere Informationen

Publikationsverlauf

26. November 2012

05. Januar 2013

Publikationsdatum:
05. April 2013 (online)

    Lizenzen und Reprints Alle Artikel dieser Rubrik

Abstract

Acute respiratory distress syndrome (ARDS) poses a major challenge in intensive care settings. The main underlying causes of ARDS are trauma, pancreatitis, and pulmonary manifestation of systemic inflammatory response syndrome/sepsis.

Lemierre syndrome represents a nearly forgotten entity arising from oropharyngeal infections with Fusobacterial species, and it is of renewed and increasing interest because of evolving antibiotic resistances.

We report two cases of young female patients afflicted by Lemierre syndrome with additional severe ARDS and present an overview of the current literature.

Keywords

Lemierre syndrome - fusobacterial infections - ARDS
 

  • References

  • 1 Brook I. Anaerobic bacteria in the upper respiratory tract and head and neck infections: Microbiology and treatment. Anaerobe 2011; ; epub ahead of print
    PubMedSuche in Google Scholar
  • 2 Brook I. Antibiotic resistance of oral anaerobic bacteria and their effect on the management of upper respiratory tract and head and neck infections. Semin Respir Infect 2002; 17 (3) 195-203
    CrossrefPubMedSuche in Google Scholar
  • 3 Centor RM, Samlowski R. Avoiding sore throat morbidity and mortality: when is it not “just a sore throat?”. Am Fam Physician 2011; 83 (1) 26-28 , 28
    PubMedSuche in Google Scholar
  • 4 Wingfield T, Blanchard TJ, Ajdukiewicz KM. Severe pneumonia and jaundice in a young man: an atypical presentation of an uncommon disease. J Med Microbiol 2011; 60 (Pt 9) 1391-1394
    CrossrefPubMedSuche in Google Scholar
  • 5 Nohrström E, Mattila T, Pettilä V , et al. Clinical spectrum of bacteraemic Fusobacterium infections: from septic shock to nosocomial bacteraemia. Scand J Infect Dis 2011; 43 (6–7) 463-470
    CrossrefPubMedSuche in Google Scholar
  • 6 Batty A, Wren MW, Gal M. Fusobacterium necrophorum as the cause of recurrent sore throat: comparison of isolates from persistent sore throat syndrome and Lemierre's disease. J Infect 2005; 51 (4) 299-306
    CrossrefPubMedSuche in Google Scholar
  • 7 Ware LB, Matthay MA. The acute respiratory distress syndrome. N Engl J Med 2000; 342 (18) 1334-1349
    CrossrefPubMedSuche in Google Scholar
  • 8 Wheeler AP, Bernard GR. Acute lung injury and the acute respiratory distress syndrome: a clinical review. Lancet 2007; 369 (9572) 1553-1564
    CrossrefPubMedSuche in Google Scholar
  • 9 Combes A, Pellegrino V. Extracorporeal membrane oxygenation for 2009 influenza A (H1N1)-associated acute respiratory distress syndrome. Semin Respir Crit Care Med 2011; 32 (2) 188-194
    Thieme ConnectPubMedSuche in Google Scholar
  • 10 Karkos PD, Asrani S, Karkos CD , et al. Lemierre's syndrome: a systematic review. Laryngoscope 2009; 119 (8) 1552-1559
    CrossrefPubMedSuche in Google Scholar
  • 11 Brazier JS. Human infections with Fusobacterium necrophorum. Anaerobe 2006; 12 (4) 165-172
    CrossrefPubMedSuche in Google Scholar
  • 12 Roberts GL. Fusobacterial infections: an underestimated threat. Br J Biomed Sci 2000; 57 (2) 156-162
    PubMedSuche in Google Scholar
  • 13 Lemierre A. Reflections on internal medicine. J Med (Oporto) 1951; 17 (429) 629-630
    PubMedSuche in Google Scholar
  • 14 Vogel LC, Boyer KM. Metastatic complications of Fusobacterium necrophorum sepsis. Two cases of Lemierre's postanginal septicemia. Am J Dis Child 1980; 134 (4) 356-358
    PubMedSuche in Google Scholar
  • 15 Dufillot D, Germaneau J, Taieb A, Fontan D, Guillard JM. Post-angina septicemia caused by Fusobacterium necrophorum in a 7-year-old child. Arch Fr Pediatr 1986; 43 (9) 719-721
    PubMedSuche in Google Scholar
  • 16 Pfeifer Y, Cullik A, Witte W. Resistance to cephalosporins and carbapenems in Gram-negative bacterial pathogens. Int J Med Microbiol 2010; 300 (6) 371-379
    CrossrefPubMedSuche in Google Scholar
  • 17 Humber CC, Albilia JB, Rittenberg B. Chronic osteomyelitis following an uncomplicated dental extraction. J Can Dent Assoc 2011; 77: b98
    PubMedSuche in Google Scholar
  • 18 Dorfman A, Shokoohi H, Taheri MR. Lemierre's syndrome and rapidly deteriorating respiratory failure in the emergency department. Am J Emerg Med 2011; ; epub ahead of print
    PubMedSuche in Google Scholar
  • 19 Rello J, Diaz E. Pneumonia in the intensive care unit. Crit Care Med 2003; 31 (10) 2544-2551
    CrossrefPubMedSuche in Google Scholar
  • 20 Sandiumenge A, Diaz E, Bodí M, Rello J. Therapy of ventilator-associated pneumonia. A patient-based approach based on the ten rules of “The Tarragona Strategy”. Intensive Care Med 2003; 29 (6) 876-883
    PubMedSuche in Google Scholar
  • 21 Escher R, Haltmeier S, von Steiger N , et al. Advanced Lemierre syndrome requiring surgery. Infection 2008; 36 (5) 495-496
    CrossrefPubMedSuche in Google Scholar
  • 22 Klinge L, Vester U, Schaper J, Hoyer PF. Severe Fusobacteria infections (Lemierre syndrome) in two boys. Eur J Pediatr 2002; 161 (11) 616-618
    CrossrefPubMedSuche in Google Scholar
  • 23 Carre AC, David JS, Mahr A, Flamens C, Fuster P, Bastien O. Use of ECMO as a salvage therapy for refractory hypoxia secondary to a Lemierre's syndrome. Ann Fr Anesth Reanim 2011; 30 (6) 512-515
    PubMedSuche in Google Scholar
  • 24 Litmathe J, Sucker C, Easo J, Wigger L, Dapunt O. Prone and ECMO – a contradiction per se?. Perfusion 2012; 27 (1) 78-82
    CrossrefPubMedSuche in Google Scholar
  • 25 Litmathe J, Dapunt O. Double ECMO in severe ARDS: report of an outstanding case and literature review. Perfusion 2010; 25 (6) 363-367
    CrossrefPubMedSuche in Google Scholar