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Synlett 2013; 24(9): 1155-1159
DOI: 10.1055/s-0033-1338439
DOI: 10.1055/s-0033-1338439
letter
BINAM-mono-PHOS as New Entry for Multinuclear Copper Catalysts in Asymmetric Conjugate Addition of Organozinc Reagents
Further Information
Publication History
Received: 13 March 2013
Accepted after revision: 02 April 2013
Publication Date:
23 April 2013 (online)


Abstract
The readily functionalized ligands, BINAM-PHOS, participate in the copper-catalyzed asymmetric conjugate addition of organozinc reagents to enones. The incorporation of benzoyl derivatives on nitrogen atoms was crucial to promote the reaction. Notably, BINAM-PHOS derivatives gave the opposite major enantiomers to that obtained using BINOL-PHOS derivatives, which we have developed for the construction of multinuclear catalysts.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synlett.
- Supporting Information