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Synthesis 2013; 45(13): 1899-1903
DOI: 10.1055/s-0033-1338495
DOI: 10.1055/s-0033-1338495
paper
Synthesis of Potent CERT Inhibitor HPA-12 Featuring a Tandem Corey–Link and Intramolecular Nucleophilic Acyl Substitution Reaction
Further Information
Publication History
Received: 22 April 2013
Accepted after revision: 28 May 2013
Publication Date:
06 June 2013 (online)
Dedicated to Prof. Scott E. Denmark on the occasion of his 60th birthday
Abstract
A novel preparation of the potent CERT protein inhibitor (1R,3S)-HPA-12 is described. The synthesis is accomplished in five steps from (S)-Wynberg lactone and features a diastereoselective tandem Corey–Link and intramolecular nucleophilic acyl substitution reaction in a key step.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information
-
References
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