Asymmetric Organocatalytic Synthesis of Spiro-cyclopropaneoxindoles

Artur Noole; Andrei V. Malkov; Tõnis Kanger

doi:10.1055/s-0033-1338505

Synthesis, Inhaltsverzeichnis

Synthesis 2013; 45(18): 2520-2524
DOI: 10.1055/s-0033-1338505

practical synthetic procedures

Asymmetric Organocatalytic Synthesis of Spiro-cyclopropaneoxindoles

Artur Noole

^aDepartment of Chemistry, Tallinn University of Technology, Akadeemia tee 15, Tallinn 12618, Estonia

,

Andrei V. Malkov

^bDepartment of Chemistry, Loughborough University, Loughborough, LE11 3TU, UK Fax: +3726202828 eMail: kanger@chemnet.ee

,

Tõnis Kanger*

^aDepartment of Chemistry, Tallinn University of Technology, Akadeemia tee 15, Tallinn 12618, Estonia

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Abstract

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Abstract

Straightforward cascade reactions for the synthesis of spiro-cyclopropaneoxindoles are described. The target compounds are obtained in high yields and in good enantio- and diastereoselectivities via hydrogen bonding or iminium catalysis.

Key words

spiro compounds - organocatalysis - oxindoles - 3-chlorooxindoles - asymmetric synthesis

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Referenzen

References

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11 CCDC 916343 contains the supplementary crystallographic data for compound 9c. This data can be obtained free of charge from The Cambridge Crystallographic Data Centre via www.ccdc.cam.ac.uk/data_request/cif.

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