Clean and Economic Synthesis of Alkanesulfonyl Chlorides from S-Alkyl Isothiourea Salts via Bleach Oxidative Chlorosulfonation

Zhanhui Yang; Bingnan Zhou; Jiaxi Xu

doi:10.1055/s-0033-1338567

Synthesis, Inhaltsverzeichnis

Synthesis 2014; 46(02): 225-229
DOI: 10.1055/s-0033-1338567

paper

Clean and Economic Synthesis of Alkanesulfonyl Chlorides from S-Alkyl Isothiourea Salts via Bleach Oxidative Chlorosulfonation

Zhanhui Yang

State Key Laboratory of Chemical Resource Engineering, Department of Organic Chemistry, Faculty of Science, Beijing University of Chemical Technology, Beijing 100029, P. R. of China Fax: +86(10)64435565 eMail: jxxu@mail.buct.edu.cn

,

Bingnan Zhou

State Key Laboratory of Chemical Resource Engineering, Department of Organic Chemistry, Faculty of Science, Beijing University of Chemical Technology, Beijing 100029, P. R. of China Fax: +86(10)64435565 eMail: jxxu@mail.buct.edu.cn

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Jiaxi Xu*

State Key Laboratory of Chemical Resource Engineering, Department of Organic Chemistry, Faculty of Science, Beijing University of Chemical Technology, Beijing 100029, P. R. of China Fax: +86(10)64435565 eMail: jxxu@mail.buct.edu.cn

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Abstract

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Abstract

A simple procedure for clean and economic synthesis of alkanesulfonyl chlorides via bleach-mediated oxidative chlorosulfonation of S-alkyl isothiourea salts is disclosed. This procedure is environment- and worker-friendly with the advantages of readily accessible materials and reagents, simple and safe operations, easy purification without chromatography, and affords high yields of up to 99%.

Key words

bleach - sulfonyl chloride - S-alkyl isothiourea - chlorosulfonation - oxidation

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Referenzen

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