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Synlett 2013; 24(14): 1801-1804
DOI: 10.1055/s-0033-1338872
letter
© Georg Thieme Verlag Stuttgart · New York

A Tandem [3+2] Cycloaddition–Elimination Cascade Reaction to Generate Pyrrolo-[3,4-c]pyrrole-1,3-diones

Guillermo Martinez-Ariza
a   Department of Pharmacology and Toxicology, College of Pharmacy, BIO5 Oro Valley, The University of Arizona, 1580 E. Hanley Blvd., Oro Valley, AZ 85737, USA   Fax: +1(520)6260794   Email: hulme@pharmacy.arizona.edu
,
Justin Dietrich
a   Department of Pharmacology and Toxicology, College of Pharmacy, BIO5 Oro Valley, The University of Arizona, 1580 E. Hanley Blvd., Oro Valley, AZ 85737, USA   Fax: +1(520)6260794   Email: hulme@pharmacy.arizona.edu
,
Fabio De Moliner
a   Department of Pharmacology and Toxicology, College of Pharmacy, BIO5 Oro Valley, The University of Arizona, 1580 E. Hanley Blvd., Oro Valley, AZ 85737, USA   Fax: +1(520)6260794   Email: hulme@pharmacy.arizona.edu
,
Christopher Hulme*
a   Department of Pharmacology and Toxicology, College of Pharmacy, BIO5 Oro Valley, The University of Arizona, 1580 E. Hanley Blvd., Oro Valley, AZ 85737, USA   Fax: +1(520)6260794   Email: hulme@pharmacy.arizona.edu
b   Department of Chemistry and Biochemistry, The University of Arizona, Tucson, AZ 85721, USA
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Further Information

Publication History

Received: 17 April 2013

Accepted after revision: 02 May 2013

Publication Date:
01 August 2013 (online)

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Abstract

An efficient tandem [3+2] cycloaddition–elimination cascade sequence has been developed enabling assembly of the pharmacologically relevant pyrrolo-[3,4-c]pyrrole-1,3-dione chemotype. The strategy involves simple mixing of readily accessible oxazolin-2-ones and pyrrole-2,5-diones in the presence of base under mild conditions, rendering the title compounds in typically excellent yields. Of note, this route allows for installation of three points of diversity and is ideal for combinatorial applications and parallel synthesis production campaigns.

Key words

cycloaddition - elimination - tandem reaction - bicyclic compounds - ylides
 

  • References and Notes

  • 1 These two authors contributed equally to this work.
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  • 17 General Procedure for the Preparation of Compounds 1 (Route B), Exemplified for Compound 1d Phenylglycine (1.0 equiv, 6.60 mmol, 1.0 g) was added to 2.0 M NaOH (20 mL) in a 100 mL round-bottomed flask. The solution was cooled to 0 °C in an ice bath, and then 4-fluorobenzoylchloride (9, 1.0 equiv, 6.60 mmol, 0.78 mL) was added dropwise over 20 min. The reaction was allowed to warm to r.t. and stirred for 2 h. The solution was then made slightly acidic (pH 5–6) by dropwise addition of 2.0 M HCl and was extracted with EtOAc (5 × 75 mL). The organic phase was dried over MgSO4 and concentrated in vacuo to yield 8d as white solid (1.6 g). 1H NMR (400 MHz, DMSO-d 6): δ = 12.96 (s, 1 H), 9.06 (d, J = 7.4 Hz, 1 H), 7.99 (dd, J = 8.4, 6.0 Hz, 2 H), 7.50–7.46 (m, 2 H), 7.39–7.24 (m, 4 H), 5.58 (d, J = 7.4 Hz, 1 H). 13C NMR (100 MHz, DMSO-d 6): δ = 172.3, 166.8, 166.6, 165.7, 163.7 (d, J C–F = 87.9 Hz), 137.4, 132.5 (d, J C–F = 12.4 Hz), 130.9 (d, J C–F = 10.1 Hz), 130.6, 128.8, 128.6, 128.4, 127.8, 116.0 (d, J C–F = 21.9 Hz), 115.5 (d, J C–F = 21.8 Hz), 57.4. MS: m/z = 274 [M + H]+. Compound 8d (5.86 mmol, 1.6 g) was then added to Ac2O (3 mL) in a 25 mL round-bottomed flask. The mixture was stirred for 2 h at r.t. and excess Ac2O was removed in vacuo via azeotroping with toluene (5 × 10 mL) to give 1.36 g of a yellow solid product (81% yield over two steps). 1H NMR (400 MHz, CDCl3): δ = 8.15–8.07 (m, 2 H), 7.50–7.35 (m, 5 H), 7.28–7.13 (m, 2 H), 5.51 (s, 1 H). 13C NMR (100 MHz, CDCl3): δ = 176.0, 166.9, 163.0 (d, J C–F = 281.9 Hz), 133.3, 130.6 (d, J C–F = 9.2 Hz), 129.0, 128.8, 128.2 (d, J C–F = 8.6 Hz), 126.8, 121.9, 116.2 (d, J C–F= 22.3 Hz), 115.9 (d, J C–F = 22.2 Hz), 68.1. MS: m/z = 256 [M + H]+.
  • 19 General Procedure for the Preparation of Compounds 2, Exemplified for Compound 2c 3-Bromomaleic anhydride (1.0 equiv, 5.65 mmol, 1.0 g) was dissolved in AcOH (20 mL). Methylamine hydrochloride (1.0 equiv, 5.65 mmol, 0.37 g) was then added, and the reaction was heated at 80 °C for 3 h. Solvent was removed in vacuo, and the crude mixture was purified by column chromatography over silica gel (EtOAc–hexane 0–30%) using an ISCOTM purification system to afford 0.97 g of a white solid (90% yield). 1H NMR (400 MHz, CDCl3): δ = 6.89 (s,1 H), 3.08 (s,3 H). 13C NMR (100 MHz, CDCl3): δ = 168.5, 165.3, 131.9, 131.3, 24.6. MS: m/z = 191 [M + H]+.
  • 20 General Procedure for the Preparation of Compounds 5, Exemplified for Compound 5a 4-Phenyl-2-(trifluoromethyl)oxazol-5(4H)-one (1a, 1.0 equiv, 1,3 mmol, 0.30 g) and 3-bromo-phenyl-1H-pyrrole-2,5-dione (2a, 1.0 equiv, 1,3 mmol, 0.33 g) were dissolved in toluene (20 mL). DIPEA (2.0 equiv, 2.6 mmol, 0.45 mL) was added. The reaction mixture was stirred at r.t. for 15 min. Solvent was evaporated in vacuo, and the crude material was purified by column chromatography over silica gel (EtOAc–Hexane 0–50%) using an ISCOTM purification system to afford 0.44 g of a yellow solid (91% yield). Crystals suitable for X-ray diffraction studies were obtained by recrystallization of the pure product from CH2Cl2 and hexane. 1H NMR (400 MHz, CDCl3): δ = 7.41 (m, 10 H), 8.44 (s, 1 H). 13C NMR (100 MHZ, CDCl3): δ = 166.4, 162.0, 134.6, 133.4, 132.8, 131.9, 130.3, 129.6, 129.2, 129.1, 128.5, 126.9, 125.9, 121.9, 119.0, 29.6 (m). MS: m/z = 357 [M + H]+.
  • 21 Complete crystallographic information for compound 5a can be found in: Roberts SA, Martinez-Ariza G, Dietrich J, Hulme C. Acta Crystallogr., Sect. E: Struct. Rep. Online 2012; 68: 496
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