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Synthesis 2013; 45(13): 1853-1856
DOI: 10.1055/s-0033-1338878
paper
© Georg Thieme Verlag Stuttgart · New York

Synthesis and Characterization of Ferrocene Acetals and Evaluation of Their Antineoplastic Properties by Using Breast Cancer Cell Lines In Vitro

Jorge Castillo-Ramirez
a   University of Puerto Rico at Humacao, Chemistry Department, Call Box 860, Humacao 00972, Puerto Rico   Fax: +787(850)9448   Email: mirna.rivera@upr.edu
,
Ileabett Echevarría
b   University of Puerto Rico Medical Sciences Campus, School of Pharmacy, PO Box 365067, San Juan 00936-5067, Puerto Rico
,
Janice Santiago
b   University of Puerto Rico Medical Sciences Campus, School of Pharmacy, PO Box 365067, San Juan 00936-5067, Puerto Rico
,
Marianela Pérez-Torres
b   University of Puerto Rico Medical Sciences Campus, School of Pharmacy, PO Box 365067, San Juan 00936-5067, Puerto Rico
,
Mirna Rivera-Claudio*
a   University of Puerto Rico at Humacao, Chemistry Department, Call Box 860, Humacao 00972, Puerto Rico   Fax: +787(850)9448   Email: mirna.rivera@upr.edu
› Author Affiliations
Further Information

Publication History

Received: 24 April 2013

Accepted: 08 May 2013

Publication Date:
05 June 2013 (online)

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To Dr. Scott E. Denmark in his 60th birthday’s celebration. With gratitude and best wishes from Dr. Mirna Rivera Claudio.

Abstract

Two new ferrocene acetals were synthesized from a chiral diol in toluene and characterized by a range of spectroscopic techniques. The biological activities of the products were evaluated by using the breast adenocarcinoma cell lines T47D, MCF7, ZR-75-1, MD-MB-468, and MD-MB-231. In comparison with tamoxifen, the ferrocene acetals showed moderate anticancer activity in vitro for the T47D and MCF7 cell lines.

Key words

acetals - organometallic compounds - iron - drugs

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    for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
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