Post Ugi Gold(I)- and Platinum(II)-Catalyzed Alkyne Activation: Synthesis of Diversely Substituted Fused Azepinones and Pyridinones

Abstract

A post-Ugi late-transition-metal-catalyzed intramolecular hydroarylation approach opens a new gateway for the synthesis of diversely substituted pyrrolopyridinones, pyrroloazepinones thiophenoazepinones, azepinoindoles, and azepinobenzothiophenes applying mild reaction conditions. A detailed investigation of the scope of this strategy is discussed.

Key words

gold - platinum - alkyne - Ugi - azepinone - pyridinone

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