A Non-infringing Route for Enantioselective Synthesis of Antiepileptic Agent Lacosamide

Abstract

A non-infringing route for enantioselective synthesis of lacosamide has been developed. The synthesis started from commercially available acrylic acid and was completed in eight steps using Sharpless asymmetric dihydroxylation as a key step with an overall yield of 29%. All the reactions were very clean with good yields.

Key words

antiepileptic agent - dihydroxylation - tosylation - azide - lacosamide

• References

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