A Mild and Simple Method for the Synthesis of Substituted Phenazines

Harpreet Kour; Satya Paul; Parvinder Pal Singh; Rajive Gupta

doi:10.1055/s-0033-1340478

Synlett, Table of Contents

Synlett 2014; 25(4): 495-500
DOI: 10.1055/s-0033-1340478

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A Mild and Simple Method for the Synthesis of Substituted Phenazines

Harpreet Kour

^aDepartment of Chemistry, University of Jammu, Jammu 180006, India Fax: +91(191)2431365 Email: paul7@rediffmail.com

,

Satya Paul*

^aDepartment of Chemistry, University of Jammu, Jammu 180006, India Fax: +91(191)2431365 Email: paul7@rediffmail.com

,

Parvinder Pal Singh

^bMedicinal Chemistry Division, Indian Institute of Integrative Medicine (CSIR), Canal Road, Jammu 180001, India

,

Rajive Gupta

^aDepartment of Chemistry, University of Jammu, Jammu 180006, India Fax: +91(191)2431365 Email: paul7@rediffmail.com

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Abstract

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Abstract

A mild, simple, and general method has been developed for the synthesis of phenazines by cross-coupling of benzoquinones with o-phenylenediamines. Benzoquinones and o-phenylenediamines reacted smoothly to give the corresponding cross-coupled products in good to excellent yields. 1,4-Naphthoquinone also coupled with o-phenylenediamines in the presence of copper acetate at 50 °C to give the corresponding benzo[a]phenazines. All reactions could be carried out under air.

Key words

cross-coupling - quinones - amines - heterocycles - cyclization - polycycles - catalysis - copper

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References

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