Palladium-Catalyzed Chelation-Assisted C–H Bond Halogenation: Selective Chlorination of 2-Arylpyridines with Acid Chlorides

Abstract

Palladium-catalyzed chelation-assisted C–H bond halogenation of arenes using acid chlorides as chlorinating agents is reported. This method provides a monoselective, straightforward, and clean route for the construction of aryl chlorides as privileged motifs in organic transformations.

Key words

aroyl chlorides - C–H activation - chlorination - palladium - 2-phenylpyridine

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