A New Enantioselective Synthesis of the Anti-Parkinson Agent Safinamide

Anjaneyulu Reddi; Mohammad Mujahid; Murugesan Sasikumar; Murugan Muthukrishnan

doi:10.1055/s-0033-1341104

Synthesis, Table of Contents

Synthesis 2014; 46(13): 1751-1756
DOI: 10.1055/s-0033-1341104

paper

A New Enantioselective Synthesis of the Anti-Parkinson Agent Safinamide

Anjaneyulu Reddi

Division of Organic Chemistry, CSIR-National Chemical Laboratory, Dr. Homibhabha Road, Pune 411 008, India Fax: +91(20)25902629 Email: m.muthukrishnan@ncl.res.in

,

Mohammad Mujahid

Division of Organic Chemistry, CSIR-National Chemical Laboratory, Dr. Homibhabha Road, Pune 411 008, India Fax: +91(20)25902629 Email: m.muthukrishnan@ncl.res.in

,

Murugesan Sasikumar

Division of Organic Chemistry, CSIR-National Chemical Laboratory, Dr. Homibhabha Road, Pune 411 008, India Fax: +91(20)25902629 Email: m.muthukrishnan@ncl.res.in

,

Murugan Muthukrishnan*

Division of Organic Chemistry, CSIR-National Chemical Laboratory, Dr. Homibhabha Road, Pune 411 008, India Fax: +91(20)25902629 Email: m.muthukrishnan@ncl.res.in

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Abstract

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Abstract

An alternative highly enantioselective synthesis of the anti-Parkinson agent safinamide from simple, commercially available, starting materials is described. The protocol might also be useful in the synthesis of structural variants of safinamide, such as ralfinamide or related analogues

Key words

medicinal chemistry - stereoselective synthesis - amides - safinamide

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References

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