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Semin Musculoskelet Radiol 2013; 17(02): 101-115
DOI: 10.1055/s-0033-1342967
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Chondrosarcoma: A Diagnostic Imager's Guide to Decision Making and Patient Management

Chika I. Logie
1   Musculoskeletal Section, American Institute for Radiologic Pathology (AIRP), Silver Spring, Maryland
3   Department of Radiology and Nuclear Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland
,
Eric A. Walker
2   Department of Radiology, Milton S. Hershey Medical Center, Pennsylvania State, Hershey, Pennsylvania
3   Department of Radiology and Nuclear Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland
,
Jonathan A. Forsberg
4   Division of Orthopaedic Oncology and Orthopaedic Research, Department of Orthopaedic Surgery, Walter Reed National Military Medical Center, Bethesda, Maryland
,
Benjamin K. Potter
4   Division of Orthopaedic Oncology and Orthopaedic Research, Department of Orthopaedic Surgery, Walter Reed National Military Medical Center, Bethesda, Maryland
,
Mark D. Murphey
1   Musculoskeletal Section, American Institute for Radiologic Pathology (AIRP), Silver Spring, Maryland
3   Department of Radiology and Nuclear Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland
› Author Affiliations
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Publication History

Publication Date:
14 May 2013 (online)

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Abstract

Chondrosarcoma is the third most common primary malignant bone tumor. Currently, outcomes are based largely on a histologic grading scale described by the World Health Organization (WHO) Classification of Bone Tumors (2002). This classification scheme possesses evident utility in the evaluation and management of higher grade tumors, but it is often unable to distinguish enchondromas from low-grade chondrosarcomas. This is problematic when low-grade lesions that are histologically similar to enchondromas demonstrate aggressive imaging features. Because histologic classification alone often belies the clinical significance of chondroid lesions, it is also important to consider radiologic staging as part of the clinical decision making process. This article focuses on medical decision support considerations relevant when confronted with this challenging subset of chondroid tumors, particularly differentiating the benign enchondroma from its notorious relative, the low-grade chondrosarcoma. In doing so, we present a review of the salient imaging features and discuss key differentiating characteristics.

Keywords

enchondroma - chondrosarcoma - chondroid tumors - cartilage tumors - histologic grading - radiologic staging
 

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