DMW - Deutsche Medizinische Wochenschrift, Table of Contents Dtsch Med Wochenschr 2013; 138(24): 1318-1321DOI: 10.1055/s-0033-1343104 Prinzip & Perspektive | Review article Genetik © Georg Thieme Verlag KG Stuttgart · New York Lange, nicht-kodierende RNAs als zentrale Regulatoren von Hämatopoese und Leukämogenese Long non-coding RNAs as central regulators of hematopoiesis and leukemogenesis S. Emmrich 1 Klinik für Pädiatrische Hämatologie und Onkologie, Medizinische Hochschule Hannover , J.-H. Klusmann 1 Klinik für Pädiatrische Hämatologie und Onkologie, Medizinische Hochschule Hannover › Author Affiliations Recommend Article Abstract Buy Article Schlüsselwörter Schlüsselwörternicht-kodierende RNA - lincRNA - T-UCR - Hämatopoese - Leukämie Keywords Keywordsnon-coding RNA - lincRNA - T-UCR - Hematopoiesis - leukemia Full Text References Literatur 1 Bertani S, Sauer S, Bolotin E et al. The noncoding RNA Mistral activates Hoxa6 and Hoxa7 expression and stem cell differentiation by recruiting MLL1 to chromatin. Mol Cell 2011; 43: 1040-1046 2 Calin GA, Liu CG, Ferracin M et al. Ultraconserved regions encoding ncRNAs are altered in human leukemias and carcinomas. Cancer Cell 2007; 12: 215-229 3 Dinger ME, Amaral PP, Mercer TR et al. Pervasive transcription of the eukaryotic genome: functional indices and conceptual implications. Brief Funct Genomic Proteomic 2009; 8: 407-423 4 Enge M, Bao W, Hedstrom E et al. MDM2-dependent downregulation of p21 and hnRNP K provides a switch between apoptosis and growth arrest induced by pharmacologically activated p53. Cancer Cell 2009; 15: 171-183 5 Guttman M, Amit I, Garber M et al. Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals. Nature 2009; 458: 223-227 6 Hu W, Yuan B, Flygare J et al. Long noncoding RNA-mediated anti-apoptotic activity in murine erythroid terminal differentiation. Genes Dev 2011; 25: 2573-2578 7 Huarte M, Guttman M, Feldser D et al. A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response. Cell 2010; 142: 409-419 8 Hung T, Wang Y, Lin MF et al. Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters. Nat Genet 2011; 43: 621-629 9 Klein U, Lia M, Crespo M et al. The DLEU2/miR-15a/16-1 cluster controls B cell proliferation and its deletion leads to chronic lymphocytic leukemia. Cancer Cell 2010; 17: 28-40 10 Kotake Y, Nakagawa T, Kitagawa K et al. Long non-coding RNA ANRIL is required for the PRC2 recruitment to and silencing of p15(INK4B) tumor suppressor gene. Oncogene 2011; 30: 1956-1962 11 Lujambio A, Portela A, Liz J et al. CpG island hypermethylation-associated silencing of non-coding RNAs transcribed from ultraconserved regions in human cancer. Oncogene 2010; 29: 6390-6401 12 Wagner LA, Christensen CJ, Dunn DM et al. EGO, a novel, noncoding RNA gene, regulates eosinophil granule protein transcript expression. Blood 2007; 109: 5191-5198 13 Wang KC, Chang HY. Molecular mechanisms of long noncoding RNAs. Mol Cell 2011; 43: 904-914 14 Zhang X, Lian Z, Padden C et al. A myelopoiesis-associated regulatory intergenic noncoding RNA transcript within the human HOXA cluster. Blood 2009; 113: 2526-2534
