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Am J Perinatol 2014; 31(02): 167-174
DOI: 10.1055/s-0033-1343770
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Urinary Neutrophil Gelatinase-Associated Lipocalin as an Early Biomarker for Prediction of Acute Kidney Injury in Preterm Infants

Yilmaz Tabel
1   Department of Pediatric Nephrology, Inonu University, Malatya, Turkey
,
Ahmet Elmas
1   Department of Pediatric Nephrology, Inonu University, Malatya, Turkey
,
Sevcan Ipek
2   Department of Pediatrics, Inonu University, Malatya, Turkey
,
Ahmet Karadag
3   Department of Neonatology, Inonu University, Malatya, Turkey
,
Ozlem Elmas
4   Department of Pediatrics, State Hospital, Malatya, Turkey
,
Fatma Ozyalin
5   Department of Biochemistry, Inonu University, Malatya, Turkey
› Author Affiliations
Further Information

Publication History

13 December 2012

27 February 2013

Publication Date:
16 April 2013 (online)

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Abstract

Background Our aims are to determine whether the urinary neutrophil gelatinase-associated lipocalin (uNGAL) can predict acute kidney injury (AKI) development in nonseptic and nonasphyxiated but critically ill preterm infants.

Methods Fifty preterm infants, gestational age (GA) between 28 and 34 weeks, were included in this case control study. Blood and urine samples were taken for blood urea nitrogen, serum creatinine, and uNGAL on postnatal (PN) days 1 and 7. uNGAL levels were measured by enzyme-linked immunoassay. Clinical and laboratory characteristics of the AKI group were compared with the non-AKI group.

Results AKI was diagnosed in six infants during the first week. The median uNGAL levels were significantly higher in the preterm infants with AKI than those of the controls on PN days 1 and 7 (p = 0.006 and p = 0.023, respectively). Backward stepwise logistic regression analysis identified that 5-minute Apgar score and uNGAL levels were significantly associated with the development of AKI, even after controlling for GA, birth weight, gender, and 1-minute Apgar score in nonseptic and nonasphyxiated but critically ill preterm infants.

Conclusions uNGAL can be useful as a predictive marker of AKI in nonseptic and nonasphyxiated but critically ill preterm infants.

Keywords

preterm - infant - acute kidney injury - urinary neutrophil gelatinase-associated lipocalin
 

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