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Planta Med 2013; 79(18): 1749-1755
DOI: 10.1055/s-0033-1351025
Natural Product Chemistry
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Isolation of Major Components from the Roots of Godmania aesculifolia and Determination of Their Antifungal Activities

Giselle Tamayo-Castillo
1   Unidad Estratégica de Acción de Bioprospección, Instituto Nacional de Biodiversidad (INBio), Santo Domingo de Heredia, Heredia, Costa Rica
2   Escuela de Química & CIPRONA, Universidad de Costa Rica, Ciudad Universitaria Rodrigo Facio, San Pedro de Montes de Oca, San José, Costa Rica
,
Víctor Vásquez
1   Unidad Estratégica de Acción de Bioprospección, Instituto Nacional de Biodiversidad (INBio), Santo Domingo de Heredia, Heredia, Costa Rica
,
María Isabel Ríos
1   Unidad Estratégica de Acción de Bioprospección, Instituto Nacional de Biodiversidad (INBio), Santo Domingo de Heredia, Heredia, Costa Rica
,
María Victoria Rodríguez
3   Farmacognosia y Biología Vegetal, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional Rosario, Rosario, Argentina
,
Godofredo Solano
1   Unidad Estratégica de Acción de Bioprospección, Instituto Nacional de Biodiversidad (INBio), Santo Domingo de Heredia, Heredia, Costa Rica
2   Escuela de Química & CIPRONA, Universidad de Costa Rica, Ciudad Universitaria Rodrigo Facio, San Pedro de Montes de Oca, San José, Costa Rica
,
Susana Zacchino
3   Farmacognosia y Biología Vegetal, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional Rosario, Rosario, Argentina
,
Mahabir P. Gupta
4   Centro de Investigaciones Farmacognósticas de la Flora Panameña, CIFLORPAN, Universidad de Panamá, Panamá, Panamá
› Author Affiliations
Further Information

Publication History

received 08 February 2013
revised 24 July 2013

accepted 05 October 2013

Publication Date:
19 December 2013 (online)

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Abstract

From the methanol root extract of Godmania aesculifolia, a species selected in a multinational OAS program aimed at discovering antifungal compounds from Latin American plants, a new chavicol diglycoside (1), the known 3,4-dihydroxy-2-(3-methylbut-2-en-1-yl)-3,4-dihydronaphthalen-1(2H)-one (2), and lapachol (3) were isolated and characterized by 1D and 2D NMR and MS techniques. Only 3 exhibited fairly good activity against a panel of clinical isolates of Cryptococcus neoformans (MIC50 between 7.8 and 31.2 µg/mL) and moderate activities against Candida spp. and non-albicans Candida spp.

Key words

Godmania aesculifolia - Bignoniaceae - lapachol - chavicol diglycoside - Trichophyton spp. - Microsporum spp. - Aspergillus spp. - Candida - Cryptococcus neoformans

Supporting Information

 

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