Different Associations of Adipokines in Lean and Healthy Adults

T. Ebert; I. Roth; J. Richter; A. Tönjes; S. Kralisch; U. Lossner; J. Kratzsch; M. Blüher; M. Stumvoll; M. Fasshauer

doi:10.1055/s-0033-1353198

Hormone and Metabolic Research, Inhaltsverzeichnis

Horm Metab Res 2014; 46(01): 41-47
DOI: 10.1055/s-0033-1353198

Humans, Clinical

Different Associations of Adipokines in Lean and Healthy Adults

T. Ebert^*

¹Department of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany

²IFB AdiposityDiseases, Leipzig University Medical Center, Leipzig, Germany

,

I. Roth^*

¹Department of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany

,

J. Richter

¹Department of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany

²IFB AdiposityDiseases, Leipzig University Medical Center, Leipzig, Germany

,

A. Tönjes

¹Department of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany

²IFB AdiposityDiseases, Leipzig University Medical Center, Leipzig, Germany

,

S. Kralisch

¹Department of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany

²IFB AdiposityDiseases, Leipzig University Medical Center, Leipzig, Germany

,

U. Lossner

¹Department of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany

²IFB AdiposityDiseases, Leipzig University Medical Center, Leipzig, Germany

,

J. Kratzsch

³Institute of Laboratory Medicine, University of Leipzig, Leipzig, Germany

,

M. Blüher

¹Department of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany

,

M. Stumvoll

¹Department of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany

,

M. Fasshauer

¹Department of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany

²IFB AdiposityDiseases, Leipzig University Medical Center, Leipzig, Germany

› Institutsangaben

Abstract

Regulation of adipokines in lean adults without metabolic disease and without eating disorders has not been comprehensively elucidated. We hypothesized that some of the established associations of these adipocyte-secreted proteins with anthropometric and biochemical measures of glucose homeostasis, lipid metabolism, renal function, as well as inflammation, differ in healthy and low weight adults as compared to overweight/obese patients. Eighty-one subjects with a body mass-index below 22.0 kg/m² and without malnutrition or eating disorders, as well as fifty overweight/obese patients, were recruited for the study. Serum concentrations of seven adipokines (adiponectin, leptin, adipocyte fatty acid-binding protein [AFABP], chemerin, fibroblast growth factor [FGF]-21, resistin, retinol-binding protein [RBP]-4) were measured by enzyme-linked immunosorbent assays. Lean probands had significantly higher levels of adiponectin and resistin, as well as lower levels of leptin, AFABP, and RBP-4, as compared to overweight/obese subjects. Serum concentrations of adiponectin, leptin, AFABP, chemerin, and resistin were significantly higher in lean women as compared to men (p<0.05). In lean subjects, fasting insulin independently predicted leptin and resistin concentrations. Furthermore, C-reactive protein was independently associated with circulating AFABP and chemerin. Moreover, lean body mass was an independent predictor of leptin, fat mass predicted AFABP levels, whereas RBP-4 was independently correlated to age and triglycerides. In addition, high density lipoprotein cholesterol predicted AFABP. Our results support the notion that several of these adipokines are regulated in a different manner in lean adults as compared to overweight/obese subjects and patients with eating disorders.

Key words

adipokines - leanness - metabolism

Volltext

Referenzen

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