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Thorac Cardiovasc Surg 2014; 62(04): 338-343
DOI: 10.1055/s-0033-1359713
Original Thoracic
Georg Thieme Verlag KG Stuttgart · New York

The Influence of Serum Sodium Concentration on Prognosis in Resected Non-Small Cell Lung Cancer

Naohiro Kobayashi
1   Department of General Thoracic Surgery, Graduate School of Comprehensive Human Science, University of Tsukuba, Tsukuba, Ibaraki, Japan
,
Shingo Usui
1   Department of General Thoracic Surgery, Graduate School of Comprehensive Human Science, University of Tsukuba, Tsukuba, Ibaraki, Japan
,
Masatoshi Yamaoka
2   Department of General Thoracic Surgery, Tsukuba University Hospital, Tsukuba, Ibaraki, Japan
,
Hisashi Suzuki
1   Department of General Thoracic Surgery, Graduate School of Comprehensive Human Science, University of Tsukuba, Tsukuba, Ibaraki, Japan
,
Shinji Kikuchi
1   Department of General Thoracic Surgery, Graduate School of Comprehensive Human Science, University of Tsukuba, Tsukuba, Ibaraki, Japan
,
Yukinobu Goto
1   Department of General Thoracic Surgery, Graduate School of Comprehensive Human Science, University of Tsukuba, Tsukuba, Ibaraki, Japan
,
Mitsuaki Sakai
1   Department of General Thoracic Surgery, Graduate School of Comprehensive Human Science, University of Tsukuba, Tsukuba, Ibaraki, Japan
,
Yukio Sato
1   Department of General Thoracic Surgery, Graduate School of Comprehensive Human Science, University of Tsukuba, Tsukuba, Ibaraki, Japan
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Publikationsverlauf

21. Juni 2013

29. September 2013

Publikationsdatum:
02. Dezember 2013 (online)

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Abstract

Background Hyponatremia is the most common electrolyte disorder and is a negative prognostic factor in several kinds of cancer. However, few reports have referred to hyponatremia in non-small cell lung cancer (NSCLC). In the present study, the authors examined the influence of preoperative serum sodium concentration on survival in completely resected NSCLC.

Methods A total of 386 completely resected NSCLC patients were retrospectively analyzed.

Results Kaplan-Meier survival curves showed that serum sodium concentration was a significant prognostic factor, and the log-rank statistical value was maximum (9.173, p = 0.002) when the cutoff value of serum sodium concentration was 139 mEq/L. The overall 5-year survival rate of the high-serum sodium concentration group (> 139 mEq/L) was 74.8% and that of the low-serum sodium concentration group (≤ 139 mEq/L) was 59.7%. Clinicopathological factors showed significant differences between the two groups for leukocyte count, neutrophil count, C-reactive protein, tumor size, and pleural invasion.

Conclusions Low-serum sodium concentration, which was associated with tumor status and inflammation, had negative prognostic influence in completely resected NSCLC.

Keywords

inflammation - systemic - lung cancer treatment - pathophysiology
 

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