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Dtsch Med Wochenschr 2014; 139(08): 369-374
DOI: 10.1055/s-0033-1360066
Originalarbeit | Original article
Diabetologie
© Georg Thieme Verlag KG Stuttgart · New York

Assoziation von Diabetes Typ 2 und Depressivität

Verhaltenspsychologische und biologische AspekteAssociation of diabetes type 2 and depression – behavioural and biological aspects
G. Wagner
1   Institut für Allgemeinmedizin, Heinrich-Heine-Universität, Universitätsklinikum Düsseldorf
,
A. Icks
2   Funktionsbereich Public Health, Medizinische Fakultät, Heinrich-Heine-Universität Düsseldorf
3   Institut für Biometrie und Epidemiologie, Deutsches Diabetes-Zentrum, Leibniz-Zentrum für Diabetesforschung an der Heinrich-Heine-Universität Düsseldorf
,
M. Redaelli
1   Institut für Allgemeinmedizin, Heinrich-Heine-Universität, Universitätsklinikum Düsseldorf
4   Institut für Gesundheitsökonomie und klinische Epidemiologie, Universitätsklinikum Köln
,
B. Albers
3   Institut für Biometrie und Epidemiologie, Deutsches Diabetes-Zentrum, Leibniz-Zentrum für Diabetesforschung an der Heinrich-Heine-Universität Düsseldorf
,
H.-H. Abholz
1   Institut für Allgemeinmedizin, Heinrich-Heine-Universität, Universitätsklinikum Düsseldorf
› Author Affiliations
Further Information

Publication History

20 February 2013

17 October 2013

Publication Date:
11 February 2014 (online)

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Zusammenfassung

Hintergrund und Fragestellung: Diabetes mellitus Typ 2 und Depression treten häufig komorbide auf. Verhaltensassoziierte Merkmale sind möglicherweise als Risikofaktor für beide Krankheiten ursächlich. Darüber hinaus lassen sich biologische Einflussfaktoren identifizieren.

Methode: Exploratorische Literaturrecherche in PubMed nach Übersichtsartikeln; anschließend eine key-word-geleitete detaillierende Recherche in Pubmed und der Cochrane Library mit den Schlagwörtern „diabetes mellitus“ AND „depression“ als Basiselement, kombiniert mit MeSH-Terms zu identifizierten relevanten Einzelaspekten wichtiger neuroendokrinologischer, neuropathologischer und neurobiochemischer Veränderungen, sowie antidepressiver Medikation.

Ergebnisse: Es fehlen gut erklärende Modelle zur komplexen Interaktion der beiden Erkrankungen in Bezug auf Verhaltensfaktoren als auch pathophysiologischen Veränderungen. Bisher sind nur zahlreiche Einzelaspekte von gemeinsamer oder interagierender Pathophysiologie bzw. Verhaltensauffälligkeiten beschrieben.

Folgerung: Intensiver Forschungsbedarf besteht für Erklärungsansätze der Komorbidität von Diabetes und Depression.

Abstract

Background and objective: Type 2 diabetes and depression often appear together. Although health behaviour and risk factors partially explain this association, other potential mechanisms have yet to be elucidated.

Methods: Explorative literature research for reviews on the topic in PubMed. Additional key-word guided research for studies in PubMed and Cochrane Library employing the keywords “diabetes” AND “depression” in combination with identified relevant single aspects (MeSH-terms) for certain neuroendocrine alterations, neuropathological und neurobiochemestric changes as well as the role of antidepressants.

Results: There are no satisfying explanatory models for the complex interaction of both diseases concerning behavioural factors and pathophysiological changes. Currently there are only many single aspects of shared or interacting pathophysiology or behaviour conspicuity.

Conclusion: The objective of this review is to summarize these aspects and their contributions to the interacting pathophysiology of the two diseases.

Schlüsselwörter

Depression - Typ 2 Diabetes mellitus - pathophysiologische Risikofaktoren - verhaltenspsychologische Risikofaktoren

Keywords

depression - type 2 diabetes - pathophysiology risk factors - behaviour related risk factors
 

  • Literatur

  • 1 Ajilore O, Haroon E, Kumaran S et al. Measurement of brain metabolites in patients with type 2 diabetes and major depression using proton magnetic resonance spectroscopy. Neuropharmacology 2007; 32: 1124-1231
    PubMedGoogle Scholar
  • 2 Andersohn F, Schade R, Suissa S et al. Long-term use of antidepressants for depressive disorders and the risk of diabetes mellitus. Am J Psychiatry 2009; 166: 591-598
    CrossrefPubMedGoogle Scholar
  • 3 Atlantis E, Browning C, Sims J et al. Diabetes incidence associated with depression and antidepressants in the Melbourne Longitudinal Studies on Healthy Ageing (MELSHA). Int J Geriatr Psychiatry 2009; 25: 688-696
    CrossrefPubMedGoogle Scholar
  • 4 Barzilay JI, Abraham I, Heckbert SR et al. The relation of markers of inflammation to the development of glucose disorders in the elderly: the Cardiovascular Health Study. Diabetes 2001; 50: 2384-2389
    CrossrefPubMedGoogle Scholar
  • 5 Bisshop MI, Kriegman DM, Deeg DJ et al. The longitudinal relation between chronic diseases and depression in older persons in the community: the Longitudinal Aging Study Amsterdam. J Clin Epidemiol 2004; 57: 187-194
    CrossrefPubMedGoogle Scholar
  • 6 Björntorp P, Holm G, Rosmond R. Hypothalamic arousal, insulin resistance and type 2 diabetes mellitus. Diabetic Medicine 1999; 16: 373-383
    CrossrefPubMedGoogle Scholar
  • 7 Brown L, Majumdar SR, Johnson JA. Type of antidepressant therapy and risk of type 2 diabetes in people with diabetes. Diabetes Res Clin Pract 2008; 79: 61-67
    CrossrefPubMedGoogle Scholar
  • 8 Cameron O, Thomas B, Tiongeo D et al. Hypercortisolism in diabetes mellitus. Diabetes Care 1987; 10: 662
    PubMedGoogle Scholar
  • 9 Capuron L, Ravaud A, Neveu PJ et al. Association between decreased serum tryptophan concentrations and depressive symptoms in cancer patients undergoing cytokine therapy. Molecular Psychiatry 2002; 7: 468-473
    CrossrefPubMedGoogle Scholar
  • 10 Carney RM, Freedland KE, Veith RC. Depression, the autonomic nervous system, and coronary heart disease. Psychosom Med 2005; 67: 29-S33
    CrossrefPubMedGoogle Scholar
  • 11 Carroll D, Phillips AC, Hunt K et al. Symptoms of depression and cardiovascular reactions to acute psychological stress: evidence from a population study. Biological Psychiatry 2007; 75: 68-74
    CrossrefPubMedGoogle Scholar
  • 12 Champaneri S, Wand GS, Malhotra SS et al. Biological basis of depression in adults with diabetes. Curr Diab Rep 2010; 396-405
    PubMedGoogle Scholar
  • 13 Chiodini I, Adda G, Scillitani A et al. Cortisol secretion in patients with type 2 diabetes. Diabetes Care 2007; 30: 83-88
    CrossrefPubMedGoogle Scholar
  • 14 Cummings JL. Frontal-subcortical circuits and human behavior. Arch Neurol 1993; 50: 873-80
    CrossrefPubMedGoogle Scholar
  • 15 De Groot M, Anderson R, Freedland K et al. Association of depression and diabetes complications: a meta-analysis. Psychosom Med 2001; 63: 619-630
    CrossrefPubMedGoogle Scholar
  • 16 Engum A, Mykletun A, Midthjiell K et al. Depression and diabetes: a large population based study of sociodemographic, lifestyle, and clinical factors associated with type 1 and type 2 diabetes. Diabetes Care 2005; 28: 1904-1909
    CrossrefPubMedGoogle Scholar
  • 17 Festa A, D´Agostino R, Tracey PR et al. Elevated levels of acute-phase proteins and plasminogen activator inhibitor-1 predict the development of type 2 diabetes: the Insulin Resistance Atherosclerosis Study. Diabetes 2002; 51: 1131-1137
    CrossrefPubMedGoogle Scholar
  • 18 Golden SH. A review of the evidence for a neuroendocrine link between stress, depression and diabetes mellitus. Curr Diab Rev 2007; 3: 252-259
    CrossrefPubMedGoogle Scholar
  • 19 Golden SH, Lazo M, Carnethon M et al. Examining a bidirectional association between depressive symptoms and diabetes. JAMA 2008; 299: 2751-2759
    CrossrefPubMedGoogle Scholar
  • 20 Goodnick PJ. Use of antidepressants in treatment of comorbid diabetes mellitus and depression as well as in diabetic neuropathy. Ann Clin Psychiatry 2001; 13: 31-41
    CrossrefPubMedGoogle Scholar
  • 21 Grassi G, Quarti-Trevano F, Seravalle G et al. Cardiovascular risk and adrenergic overdrive in the metabolic syndrome. Nutrition, Metabolism and Cardiovascular Disease 2007; 17: 473-481
    CrossrefPubMedGoogle Scholar
  • 22 Harvey BH, Bouwer CD. Neuropharmacology of paradoxic weight gain with selective reuptake inhibitors. Clin Neuropharmacol 2000; 23: 90-97
    CrossrefPubMedGoogle Scholar
  • 23 Hennings JM, Owashi T, Binder EB et al. Clinial characteristics and treatment outcome in a representative sample of depressed inpatients-findings from the Munic Antidepressant Response Signature (MARS) project. J Psychiatr Res 2009; 43: 215-229
    CrossrefPubMedGoogle Scholar
  • 24 Hirschfeld RMA. Long-term side effects of SSRIs: sexual dysfunction and weight gain. J Clin Psychiatry 2003; 64 (Suppl. 18) 20-24
    CrossrefPubMedGoogle Scholar
  • 25 Holsboer F. Stress, hypercortisolism and corticoid receptors in depression: implications for therapy. J Affect Disord 2001; 62: 77-91
    CrossrefPubMedGoogle Scholar
  • 26 Hudson J, Hudson MS, Rothschild AJ et al. Abnormal results of dexamethasone suppression tests in nondepressed patients with diabetes mellitus. Arch Gen Psychiatry 1984; 41: 1086-1089
    CrossrefPubMedGoogle Scholar
  • 27 Kaneto H, Katakami N, Matsuhisa M et al. Role of reactive oxygen species in the progression of type 2 diabetes and atherosclerosis. Mediators of Inflammation 2010; DOI: 10.1155/2010/453892.
    PubMedGoogle Scholar
  • 28 Katon WJ. Clinical and health services relationships between major depression, depressive symptoms, and general medical illness. Biol Psychiatry 2003; 54: 216-226
    CrossrefPubMedGoogle Scholar
  • 29 Kemp AH, Quintana DS, Gray MA et al. Impact of depression and antidepressant treatment on heart rate variability: a review and meta-analysis. Biol Psychiatry 2010; 67: 1067-1074
    CrossrefPubMedGoogle Scholar
  • 30 Kent S, Bluthe RM, Kelley KW et al. Sickness behavior as a new target for drug development. Trends in Pharmacological Science 1992; 13: 24-28
    CrossrefPubMedGoogle Scholar
  • 31 Kern PA, Saghizadeh M, Ong JM et al. The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoptotein lipase. J Clin Invest 1995; 95: 2111-2119
    CrossrefPubMedGoogle Scholar
  • 32 Khoza S, Barner JC, Bohmann TM et al. Use of antidepressant agents and the risk of type 2 diabetes. Eur J Clin Pharmacol 2012; 68: 1295-1302
    CrossrefPubMedGoogle Scholar
  • 33 Kivimäki M, Hamer M, Batty GD et al. Antidepressant medication use, weight gain, and risk of type 2 diabetes. Diabetes Care 2010; 33: 2611-2616
    CrossrefPubMedGoogle Scholar
  • 34 Knol MJ, Geeling MI, Egberts AC et al. No increased incidence of diabetes in antidepressant users. International Journal of Clinical Psychopharmacology 2007; 22: 282-286
    PubMedGoogle Scholar
  • 35 Krabbe KS, Nielsen AR, Krogh-Madsen R et al. Brain-derived neurotrophic factor (BDNF) and type 2 diabetes. Diabetologia 2007; 50: 431-438
    CrossrefPubMedGoogle Scholar
  • 36 Kumar A, Gupta R, Thomas A et al. Focal subcortical biophysical abnormalities in patients diagnosed with type 2 diabetes and depression. Arch Gen Psychiatry 2009; 66: 324-330
    CrossrefPubMedGoogle Scholar
  • 37 Laske C, Eschweiler G. Brain-derived neurotrophic factor. Der Nervenarzt 2006; 77: 523-537
    CrossrefPubMedGoogle Scholar
  • 38 Licht CM, de Geus EJ, Zitman FG et al. Association between major depressive disorder and heart rate variability in the Netherlands Study of Depression and Anxiety (NESDA). Arch Gen Psychiatry 2008; 65: 1358-1367
    CrossrefPubMedGoogle Scholar
  • 39 Lustman PJ, Griffith LS, Clouse RE et al. Effects of nortriptyline on depression and glycemic control in diabetes: results from a double-blind placebo-controlled trial. Psychosom Med 1997; 59: 241-250
    PubMedGoogle Scholar
  • 40 Lysy Z, Da Costa D, Dasgupta K. The association of physical activity and depression in Type 2 diabetes. Diabetic Medicine 2008; 25: 1133-1141
    CrossrefPubMedGoogle Scholar
  • 41 Maes M. An intriguing and hitherto unexplained co-occurrence: Depression and chronic fatigue syndrome are manifestations of shared inflammatory, oxidative and nitrosative (IO&NS) pathways. Prog Neuropsychopharmacol Biol Psychiatry 2011; 35: 784-794
    CrossrefPubMedGoogle Scholar
  • 42 Maes M, Kubera M, Obuchowiczwa E et al. Depression`s multiple comobidities explained by (neuro ) inflammatory and oxidative & nitrosative stress pathways. Neuro Endocrinol Lett 2011; 32: 7-24
    PubMedGoogle Scholar
  • 43 McIntyre RS, Soczynska JK, Konarski JZ et al. The effect of antidepressants on glucose homeostasis and insulin sensitivity: synthesis and mechanisms. Expert Opin Drug Saf 2006; 5: 157-168
    CrossrefPubMedGoogle Scholar
  • 44 Mezuk B, Eaton WW, Albrecht S et al. Depression and type 2 diabetes over a lifespan: a meta-analysis. Diabetes Care 2008; 31: 2383-2391
    CrossrefPubMedGoogle Scholar
  • 45 Musselman DL, Betan E, Larsen H et al. Relationship of depression to diabetes type 1 and 2: epidemiology, biology, and treatment. Biol Psychiatry 2003; 54: 317-329
    CrossrefPubMedGoogle Scholar
  • 46 Pan A, Sun Q, Okerke OI et al. Use of antidepressant medication and the risk of type 2 diabetes: results from three cohorts of US adults. Diabetologia 2012; 55: 63-72
    CrossrefPubMedGoogle Scholar
  • 47 Penninx BWJH, Milaneschi Y, Lamers F et al. Understanding the somatic consequences of depression: biological mechanisms and the role of depression symptom profile. BMC Med 2013; 11: 129-143
    CrossrefPubMedGoogle Scholar
  • 48 Pertsov SS, Balashova TS, Kubatieva AA et al. Lipid peroxidation and antioxidant enzymes in rat brain in acute emotional stress: effect of interleukin-1beta. Bull Exp Biol Med 1995; 120: 244-247
    PubMedGoogle Scholar
  • 49 Pickup JC. Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes. Diabetes Care 2004; 27: 813-823
    CrossrefPubMedGoogle Scholar
  • 50 Polsky D, Doshi JA, Marcus S et al. Long-term risk of depressive symptoms after a medical diagnosis. Arch Intern Med 2005; 165: 1260-1266
    CrossrefPubMedGoogle Scholar
  • 51 Pradhan AD, Manson JE, Rifai N et al. C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA 2001; 286: 327-334
    CrossrefPubMedGoogle Scholar
  • 52 Prestle S, Aldenhoff J, Reiff J. Die HPA-Achse als mögliches Bindeglied zwischen Depression und Diabetes mellitus und kognitiven Störungen. Fortschr Neurol Psychiatr 2003; 71: 24-36
    Article in Thieme ConnectPubMedGoogle Scholar
  • 53 Purnell JQ, Kahn SE, Samuels MH et al. Enhanced cortisol production rate, free cortisol, and 11 beta HSD 1 expression correlate with visceral fat and insulin resistance in men: effect of weight loss. Am J Physiol Endocrinol Metab 2009; 296: E351-E357
    PubMedGoogle Scholar
  • 54 Raadsher FC, Hoogendijk WJ, Stam FC et al. Increased numbers of corticotropin –releasing hormone expressing neurons in the hypothalamic paraventricular nucleus of depressed patients. Neuroendocrinology 1994; 60: 436-443
    CrossrefPubMedGoogle Scholar
  • 55 Raison CL, Demetrashvili M, Capuron L et al. Neuropsychiatric adverse effects of interferon-alpha: recognition and management. CNS Drugs 2005; 19: 105-123
    CrossrefPubMedGoogle Scholar
  • 56 Rao U, Poland RE. Electroencephalographic sleep and hypothalamic –pituitary-adrenal changes from episode in recovery in depressed adolescents. J Child Adolesc Psychopharmacol 2009; 34: 1936-1945
    PubMedGoogle Scholar
  • 57 Regen F, Merkl A, Heuser I et al. Diabetes und Depression. Dtsch med Wochenschr 2005; 130: 1097-1102
    Article in Thieme ConnectPubMedGoogle Scholar
  • 58 Ross R. Atherosclerosis: an inflammatory disease. N Engl J Med 1999; 340: 115-126
    CrossrefPubMedGoogle Scholar
  • 59 Rottenberg J. Cardiac vagal control in depression: a critical analysis. Biological Psychology 2007; 74: 200-211
    CrossrefPubMedGoogle Scholar
  • 60 Roy M, Collier B, Roy A. Hypothalamic-pituary-adrenal axis dysregulation among diabetic outpatients. Psychiatry Research 1989; 31: 31-37
    PubMedGoogle Scholar
  • 61 Rubin RR, Yong MA, Marrero DG et al. Elevated depression symptoms, antidepressant medicine use, and risk of developing diabetes during the Diabetes Prevention program. Diabetes Care 2008; 31: 420-427
    CrossrefPubMedGoogle Scholar
  • 62 Rubin RR. Comorbid Depression and Diabetes. Natural history and clinical aspects. In: LeRoith D, Vinik AI. Contemporary Endocrinology: Controversies in treating diabetes: Clinical and research aspects. Totowa, NJ: Humana Press; 2008
    CrossrefGoogle Scholar
  • 63 Rustad JK, Musselman DL, Nemeroff CB. The relationship of depression and diabetes: pathophysiological and treatment implications. Psychoneuroendocrinology 2011; 36: 1276-1286
    CrossrefPubMedGoogle Scholar
  • 64 Saghizadeh M, Ong JM, Garvey WT et al. The expression of THF-α by human muscle. Relationship to insulin resistance. J Clin Invest 1996; 97: 1111-1116
    CrossrefPubMedGoogle Scholar
  • 65 Sambamoorthi U, Ma Y, Findley PA et al. Antidepressant use, depression, and new onset diabetes among elderly Medicaire Beneficiaries. J Diabetes DOI: 10.1111/1753-0407.12014.
    PubMedGoogle Scholar
  • 66 Schmidt MI, Duncan BB, Sharrett AR et al. Markers of inflammation and prediction of diabetes mellitus in adults (Atherosclerosis Risk in Communities study): a cohort study. Lancet 1999; 353: 1649-1652
    CrossrefPubMedGoogle Scholar
  • 67 Shelton RC, Miller AH. Eating ourselves to death (and despair): the contribution of adiposity and inflammation to depression. Prog Neurobiol 2010; 91: 275-299
    CrossrefPubMedGoogle Scholar
  • 68 Skala JA. Hypothesis 5: Treatment of depression may reduce the risk of diabetes and its complications. Diabetes Spectrum 2004; 17: 158-159
    CrossrefPubMedGoogle Scholar
  • 69 Sosnovskii AS, Kozlov AV. Increased lipid peroxidation in the rat hypothalamus after short-term emotional stress. Bull Exp Biol Med 1992; 113: 486-488
    CrossrefPubMedGoogle Scholar
  • 70 Stein PK, Barzilay JL, Domitrovich PP et al. The relationship of heart rate and heart rate variability to non-diabetic fasting glucose levels and the metabolic syndrome. The Cardiovascular Health Study. Diabetic Medicine 2007; 24: 855-863
    CrossrefPubMedGoogle Scholar
  • 71 Sternberg EM. The stress response and the regulation of inflammatory disease. Ann Intern Med 1992; 117: 854-866
    CrossrefPubMedGoogle Scholar
  • 72 Stetler C, Miller GE. Depression and hypothalamic-pituary-adrenal activation. Summary of four decades of research. Psychosom Med 2011; 73: 114-126
    CrossrefPubMedGoogle Scholar
  • 73 Stuart MJ, Baune BT. Depression and type 2 diabetes: inflammatory mechanisms of a psychoneuroendocrine co-morbidtity. Neurosci Biobehav Rev 2012; 36: 658-676
    CrossrefPubMedGoogle Scholar
  • 74 Taylor CB, Conrad A, Wilhelm FH et al. Psycho-physiological and cortisol responses to psychological stress in depressed and nondepressed older men and women with elevated cardiovascular disease risk. Psychosom Med 2006; 68: 538-546
    CrossrefPubMedGoogle Scholar
  • 75 Tyler WJ, Alonso M, Bramham CR et al. From acquisition to consolidation: on the role of brain-derived neurotrophic factor signaling in hippocampal-dependent learning. Learn Mem 2002; 9: 224-237
    CrossrefPubMedGoogle Scholar
  • 76 Wagner G, Icks A, Albers B et al. Typ 2 Diabetes mellitus und Depressivität: was ist ursächlich für was? Eine systematische Literaturübersicht. Dtsch med Wochenschr 2012; 137: 523-528
    Article in Thieme ConnectPubMedGoogle Scholar
  • 77 Wang X, Bao W, Liu J et al. Inflammatory markers and risk of type 2 diabetes. A systematic review and meta-analysis. Diabetes Care 2013; 36: 166-175
    CrossrefPubMedGoogle Scholar