Protective Effects of Crocin on Hemodynamic Parameters and Infarct Size in Comparison
                    with Vitamin E after Ischemia Reperfusion in Isolated Rat Hearts

Mahin Dianat; Mahdi Esmaeilizadeh; Mohammad Badavi; Alireza Samarbafzadeh; Bahareh Naghizadeh

doi:10.1055/s-0033-1360383

Planta Medica, Inhaltsverzeichnis

Planta Med 2014; 80(05): 393-398
DOI: 10.1055/s-0033-1360383

Biological and Pharmacological Activity

Original Papers

Georg Thieme Verlag KG Stuttgart · New York

Protective Effects of Crocin on Hemodynamic Parameters and Infarct Size in Comparison with Vitamin E after Ischemia Reperfusion in Isolated Rat Hearts

Mahin Dianat

¹Department of Physiology and Physiology Research Center, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

,

Mahdi Esmaeilizadeh

²Ph.D. Student, Department of Physiology and Physiology Research Center, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

,

Mohammad Badavi

¹Department of Physiology and Physiology Research Center, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

,

Alireza Samarbafzadeh

³Department of Virology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

,

Bahareh Naghizadeh

⁴Department of Pharmacology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

› Institutsangaben

Abstract

Although reperfusion is a useful method for the survival of ischemic heart, harmful effects have been observed. This study was carried out to investigate the preconditioning and cardioprotective potential effects of crocin and vitamin E on the hemodynamic and infarct size in the ischemia-reperfusion model of isolated rat hearts. Animals were divided into a control group, an ischemia-reperfusion control group and three treatment groups: crocin (10, 20, and 40 mg/kg), vitamin E (100 mg/kg), and combination (crocin 40 mg/kg with vitamin E 100 mg/kg). The hearts were excised, quickly transferred to a Langendorff apparatus, and subjected to 30 min of global ischemia followed by 60 min of reperfusion. Left ventricular developed pressure, coronary perfusion pressure, left ventricular systolic pressure, myocardial contractility, rate pressure product, coronary flow, and infarct size were assessed. The successful induction of ischemia was determined by ST elevation on the electrocardiogram.

The results showed that crocin significantly improved cardiac dysfunction and also reduced infarct size in the rat hearts. However, the combination of crocin 40 mg/kg and vitamin E 100 mg/kg had an even more significantly improved effect on the hemodynamic parameters and infarct size.

Therefore, it can be suggested that the protective role of crocin may be due to the stability or reinforcement of antioxidant systems, and crocin could be useful for the treatment or prevention of cardiac dysfunction.

Key words

hemodynamic - infarct size - crocin - Crocus sativus - Iridaceae - vitamin E - ischemia-reperfusion - rat

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Referenzen

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