Drug Res (Stuttg) 2014; 64(12): 693-694
DOI: 10.1055/s-0034-1367036
Short Communication
© Georg Thieme Verlag KG Stuttgart · New York

In Silico vs. In vivo Human Intestinal Permeability

N. M. Idkaidek
1   College of Pharmacy and International Pharmaceutical Research Center, University of Petra, Amman, Jordan
,
N. Najib
1   College of Pharmacy and International Pharmaceutical Research Center, University of Petra, Amman, Jordan
› Author Affiliations
Further Information

Publication History

received 16 November 2013

accepted 19 January 2014

Publication Date:
10 February 2014 (online)

Abstract

The aim of this research is to calculate human intestinal permeability in silico and correlate results with those measured in vivo. Optimized human intestinal permeability values were calculated for 16 drugs by de-convolution of human plasma profiles using Parameter Estimation module of SimCYP program V13. Results showed high in silico-in vivo correlation coefficient of 0.89 for drugs with high/low permeability values. In silico permeability, if properly optimized, can be used as surrogate for in vivo permeability for BCS class I drugs and hence is suggested that such methodology could be employed as a support for waiver of in vivo studies.