Effect of Type 2 Diabetes Mellitus on Pulmonary Function

H. Huang; Q. Guo; L. Li; S. Lin; Y. Lin; X. Gong; J. Yao; J. Liang; L. Lin; J. Wen; G. Chen

doi:10.1055/s-0034-1372579

Experimental and Clinical Endocrinology & Diabetes, Table of Contents

Exp Clin Endocrinol Diabetes 2014; 122(06): 322-326
DOI: 10.1055/s-0034-1372579

Article

Effect of Type 2 Diabetes Mellitus on Pulmonary Function

H. Huang^*

¹Department of Endocrinology, Fujian Provincial Hospital Key Laboratory of Endocrinology, Fujian Medical University, Fuzhou, China

,

Q. Guo^*

¹Department of Endocrinology, Fujian Provincial Hospital Key Laboratory of Endocrinology, Fujian Medical University, Fuzhou, China

,

L. Li

¹Department of Endocrinology, Fujian Provincial Hospital Key Laboratory of Endocrinology, Fujian Medical University, Fuzhou, China

,

S. Lin

¹Department of Endocrinology, Fujian Provincial Hospital Key Laboratory of Endocrinology, Fujian Medical University, Fuzhou, China

,

Y. Lin

¹Department of Endocrinology, Fujian Provincial Hospital Key Laboratory of Endocrinology, Fujian Medical University, Fuzhou, China

,

X. Gong

¹Department of Endocrinology, Fujian Provincial Hospital Key Laboratory of Endocrinology, Fujian Medical University, Fuzhou, China

,

J. Yao

¹Department of Endocrinology, Fujian Provincial Hospital Key Laboratory of Endocrinology, Fujian Medical University, Fuzhou, China

,

J. Liang

¹Department of Endocrinology, Fujian Provincial Hospital Key Laboratory of Endocrinology, Fujian Medical University, Fuzhou, China

,

L. Lin

¹Department of Endocrinology, Fujian Provincial Hospital Key Laboratory of Endocrinology, Fujian Medical University, Fuzhou, China

,

J. Wen

¹Department of Endocrinology, Fujian Provincial Hospital Key Laboratory of Endocrinology, Fujian Medical University, Fuzhou, China

,

G. Chen

¹Department of Endocrinology, Fujian Provincial Hospital Key Laboratory of Endocrinology, Fujian Medical University, Fuzhou, China

› Author Affiliations

Abstract

Background: Type 2 diabetes mellitus (T2DM) is a metabolic disease with debilitating effects on multiple organs. The alveolar-capillary network in the lung is a large microvascular unit which may be affected by T2DM-associated microangiopathy.

Methods: This retrospective study investigated whether type 2 diabetes mellitus (T2DM) affected pulmonary function. Of the 584 patients enrolled in the study, 292 had T2DM and 292 did not. Forced expiratory volume in one second (FEV₁), forced vital capacity (FVC), maximum voluntary ventilation (MVV) and total lung capacity (TLC) are values as percent of predicted, as well as FEV₁/FVC ratio which were values measured.

Results: FEV₁, FVC, FEV₁/FVC ratio, MVV, and TLC were significantly lower in T2DM than in non-T2DM (P-values<0.010). Multiple linear regression analysis found that for the entire study population fasting plasma glucose levels was negatively associated with FEV₁, FVC, FEV₁/FVC ratio and maximum voluntary ventilation (P-values<0.030). Patients with T2DM were negatively associated with total lung capacity (P-values=0.025). Multiple linear regression analysis found for patients with T2DM that fasting plasma glucose was negatively associated with FEV₁, FVC, FEV₁/FVC ratio and maximum voluntary ventilation (P-values<0.020). In T2DM patient, height was negatively correlated with FEV₁ and FVC (all P-values<0.020), triglycerides were negatively correlated with FEV₁/FVC ratio (P-values=0.048), and creatinine was negatively correlated with total lung capacity (P-values=0.017).

Conclusions: In summary, T2DM is associated with impaired pulmonary function consistent with obstructive ventilation pattern and fasting plasma glucose is an independent risk factor of reduced pulmonary function.

Key words

blood glucose - pulmonary function - type 2 diabetes mellitus

Full Text

References

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